甲巯咪唑联合雷公藤多苷片治疗甲亢的临床观察.docVIP

甲巯咪唑联合雷公藤多苷片治疗甲亢的临床观察 　　[摘要] 目的 观察分析甲巯咪唑联合雷公藤多苷片治疗甲亢的临床效果。 方法 选取2011年1月~2013年12月本院收治的92例甲亢患者为研究对象，将患者遵循随机分配的原则分为对照组（甲巯咪唑组）46例和观察组（甲巯咪唑联合雷公藤多苷片组）46例，比较两组的总有效率和治疗前后疾病的相关血清指标水平。 结果 观察组的总有效率明显高于对照组，而治疗后的疾病相关血清指标水平改善情况显著好于对照组（P0.05）。 结论 甲巯咪唑联合雷公藤多苷片治疗甲亢的临床效果明显好于单用甲巯咪唑，对疾病相关指标的改善更为明显。 　　[关键词] 甲巯咪唑；雷公藤多苷片；甲亢；临床效果 　　[中图分类号] R581.1[文献标识码] A[文章编号] 1674-4721（2014）06（a）-0079-03 　　 　　Clinical observation of methimazole combined with tripterygium glycosides tablet in the treatment of hyperthyreosis 　　WANG Li-ping 　　Department of Endocrinology,the Third People′s Hospital of Luoyang City,Luoyang 471002,China 　　[Abstract] Objective To observe and analyze the clinical effect of methimazole combined with tripterygium glycosides tablet in the treatment of hyperthyreosis. Methods 92 patients with hyperthyreosis in our hospital from January 2011 to December 2013 were selected as study objects,and they were divided into the control group (the methimazole group,n=46) and the observation group (the methimazole combined with tripterygium glycosides tablet group,n=46) by the random allocation principle,the total then the total effective rate and disease related serum indexes before and after treatment of two groups were compared. Results The total effective rate of the observation group was obviously higher than that in the control group,the disease related serum indexes after treatment were all significantly better than those in the control group (P0.05). Conclusion The clinical effect of methimazole combined with tripterygium glycosides tablet in the treatment of hyperthyreosis is better than that of only methimazole,and its improvement of the disease related indexes is more obvious. 　　[Key words] Methimazole;Tripterygium glycosides tablet;Hyperthyreosis；Clinical effect 　　甲亢是内分泌常见疾病之一，患者除表现为机体代谢亢进和交感神经兴奋等外，还往往伴有明显的抗氧化能力受损及骨代谢异常等，因此对于本类患者的治疗应注意对上述方面的改善，同时其也成为评估用药治疗有效程度及可取程度的重要指标[1]。临床上近年来对于甲亢的治疗多采用甲巯咪唑，虽然效果较好，但仍需进一步提升，因此找到较佳的联合应用药物极为必要，而近年来临床上出现较多采用甲巯咪唑联合雷公藤多苷片进行治疗的研究，但是研究差异较大，