硫普罗宁治疗酒精性肝病的临床研究.docVIP

硫普罗宁治疗酒精性肝病的临床研究 　　doi：10.3969/j.issn.1007-614x.2014.14.20 　　摘 要 目的：观察硫普罗宁注射液治疗酒精性肝病的疗效。方法：将100例酒精性肝病患者随机分成治疗组和对照组，各50例。在综合治疗基础上，治疗组予硫普罗宁注射液0.4g，加入5%葡萄糖注射液中静滴，对照组甘草酸二胺150mg静滴，疗程均为1个月。治疗前后分别检测两组血清总胆红素（TBil）、丙氨酸氨基转移酶（ALT）和门冬氨酸氨基转移酶（AST），并对照两组疗效。结果：治疗组总有效率94.0%，对照组总有效率78.0%，组间差异有统计学意义（P0.05）；治疗组肝功能改善情况明显优于对照组，组间差异有统计学意义（P0.05）；两组治疗过程中均未出现明显不良反应。结论：硫普罗宁治疗酒精性肝病疗效确切，优于甘草酸二胺。 　　关键词 硫普罗宁 酒精性肝病 临床研究 　　The sulfur proletariat rather treats alcoholic liver diseases clinical research 　　Zhu Dengling 　　Kaifeng Mabel Burns ASUs Hospital of Henan province，475002 　　Abstract Objective：To observe the sulfur proletariat rather inoculation fluid treatment alcoholic liver disease’s curative effect.Methods： 100 patient with alcoholic liver disease were randomly divides into the treatment group and the control group，each group have 50 cases.Given the treatment group sulfur proletariat inoculation fluid 0.4 to join 5% glucose inoculation fluid median vein drop note upon the complex therapy，the control group for the glycyrrhizic acid diamidogen 150 mgvein drop note，and the treatment course is 1 month. Examines blood serum total bilirubin（TBil），alanin atmosphere base transferase（ALT）and asparagus atmosphere sour amino transferase（AST）of two groups before and after the treatment separately，and compares two groups of curative effects.Results：Treatment group total effectiveness is 94.0%，while control group total effectiveness is 78.0%.The difference between two groups was Statistically significant（P0.05）；The treatment group liver function improvement situation obvious good in the control group，and the difference was statistically significant（P0.05）.There was no obvious untoward presented in courses of trearment among two groups.Conclusion： The effect of sulfur proletariat treated with alcoholic liver disease was accurate，better than the glycyrrhizic acid diamidogen treatment effect. 　　Key words Ulfur proletariat rather；Aloholic liver disease；Clinical；Studies 　　近年来，我国酒精性肝病的发病率逐年提高，其中很