- 1、本文档共14页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
ThegutmicrobiotaprofileisassociatedwithinsulinThegutmicrobiotaprofileisassociatedwithinsulin
Acta Diabetologica
??The Author(s)?2012
10.1007/s00592-012-0410-5
Original Article
The gut microbiota profile is associated with insulin action in humans
Matteo?Serino1, 2??,?José?Manuel?Fernández-Real3??,?Eduardo?García?Fuentes4,?Maribel?Queipo-Ortu?o4,?José?María?Moreno-Navarrete3,?álex?Sánchez5, 6,?Rémy?Burcelin1, 2?andFrancisco?Tinahones4
(1)
Institut National de la Santé et de la Recherche Médicale (INSERM), Toulouse, France
(2)
Unité Mixte de Recherche (UMR) 1048, Institut de Maladies Métaboliques et Cardiovasculaires (I2MC), Université Paul Sabatier (UPS), 31432?Toulouse Cedex 4, France
(3)
Department of Diabetes Endocrinology and Nutrition, Institut d’Investigació Biomédica de Girona, and CIBER Fisiopatologia Obesidad y Nutricion (CB06/03/010), Instituto de Salud Carlos III, Girona, Spain
(4)
Service of Endocrinology and Nutrition, Hospital Clinico Universitario Virgen de Victoria de Malaga and CIBEROBN (CB06/03/010), Instituto de Salud Carlos III, Madrid, Spain
(5)
Statistics Department, Facultat de Biologia UB, University of Barcelona, Avda Diagonal 645, 08028?Barcelona, Spain
(6)
Institut de Recerca, Hospital Universitari Vall’Hebron, Passeig Vall d’Hebron 112-119, 08035?Barcelona, Spain
?
?
Matteo?Serino?(Corresponding author)
Email:?matteo.serino@inserm.fr
?
José?Manuel?Fernández-Real?(Corresponding author)
Email:?jmfreal@
Received:?1?March?2012Accepted:?29?May?2012Published online:?19?June?2012
Communicated by Massimo Federici.
Abstract
The role of the gut microbiota in the induction of metabolic diseases has now been increasingly recognized worldwide. Indeed, a specific gut microbiota has been shown to characterize lean versus obese phenotypes both in humans and mice. We have also recently demonstrated that a precise gut microbiota is associated with the host’s responsiveness to a high-fat diet. Therefore, we hypothesized that insulin resistance in humans could also be linked to a specific gut microbiota. To this aim, microbial DNA and RNA were extrac
您可能关注的文档
- Ten Questions Every Director Should Ask About FCPA Compliance.docx
- Test Seven.doc
- Test 3 (U3-4, B1)试题.doc
- Test 8江苏英语三级试题.doc
- Test bank International Finance MCQ (word)Chap 17.doc
- Test bank International Finance MCQ (word)Chap 15.doc
- Test 1,江苏英语三级试题.doc
- Test bank International Finance MCQ (word)Chap 1.doc
- Test bank International Finance MCQ (word)Chap 19.doc
- Test bank International Finance MCQ (word)Chap 20.doc
文档评论(0)