翻译2013-12翻译2013-12.docxVIP

Biochemistry.?2013 Dec 13. [Epub ahead of print]Molecular?Origin?of the?Binding?of?WWOX?Tumor?Suppressor?to?ErbB4?Receptor?Tyrosine?Kinase.Schuchardt BJ,?Bhat V,?Mikles DC,?McDonald CB,?Sudol M,?Farooq A.Author informationAbstractThe ability of?WWOX?tumor?suppressor?to physically associate with the intracellular domain (ICD) of?ErbB4?receptor?tyrosine?kinase?is believed to play a central role in downregulating the transcriptional function of the latter. Herein, using various biophysical methods, we show that while the WW1 domain of?WWOX?binds to PPXY motifs located within the ICD of?ErbB4?in a