张国强-异维A酸红霉素凝胶治疗轻中度寻常性痤疮临床观察..docVIP

异维A酸红霉素凝胶治疗轻中度寻常性痤疮临床观察 张国强 王文氢 康瑞花 王曙霞 王正想 高顺强 摘要 目的：观察异维A酸红霉素凝胶治疗轻中度寻常性痤疮的疗效和安全性。方法：采用单盲随机阳性药物对照的临床试验。治疗组采用异维A酸红霉素凝胶，每晚外用1次；对照组采用他扎罗汀乳膏，每晚外用1次,连续应用56天。结果：治疗后，两组皮损数目均减少。治疗组和对照组有效率分别为80.56%和65.71%，有统计学差异 (P0.05)；两组不良反应发生率分别为13.89%和21.34%，差异无统计学意义 (P0.05)。结论：异维A酸红霉素凝胶治疗轻中度寻常性痤疮安全有效，值得临床推广应用。 关键词：痤疮；寻常性；治疗；异维A酸；红霉素 Clinical Application and Efficacy of Isotretinoin Erythromycin Gel for Mild to Moderate Acne Vulgaris ZHANG Guo-qiang, WANG Wen-qing, KANG Rui-hua, WANG Shu-xia, WANG Zheng-xiang, GAO Shun-qiang Department of Dermatology, the Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang 050011，China [Corresponding author] GAO Shun-qiang，Gaoshunqiang@ Abstract Objective To evaluate the efficacy and safety of isotretinoin erythromycin gel in the treatment of mild to moderate acne vulgaris. Methods By a single-blind randomized controlled method, a total of 160 patients with mild to moderate acne vulgaris were assigned to one of the following two groups: the trail group which was treated with isotretinoin erythromycin gel(80 cases), while the control group was treated with tazarotene cream(80 cases). After treatment for 56 consecutive days with each drug respectively smeared on the surface individually every night, the efficacy and safety were investigated. Results The number of skin lesions in both of the two groups was reduced. Effective rate for the trial group was 80.56%, the control group was 65.71%, with significant difference between them (P0.05). The adverse reactions were 13.89%% and 21.34% in the trial and control group respectively, with no significant difference between them (P0.05).Conclusion Isotretinoin erythromycin gel is a safe and more effective drug in the treatment of mild to moderate acne vulgaris compared with tazarotene cream. Key words: Acne ; Vulgaris; Treatment; Isotretinoin; Erythromycin 寻常性痤疮是皮肤科常见的一种慢性毛囊皮脂腺炎症性疾病。2009年9月－2010年3月，本科应用异维A酸红霉素凝胶治疗寻常性痤疮72例，取得了满意疗效，现报告如下。 1资料与方法 1.1 临床资料 1.1.1 入选标准 受试者年龄在18~35岁之间；临床症状和