postoperative chemotherapy for gastric cancer.docVIP

Postoperative Chemotherapy for Gastric Cancer nbsp;nbsp;nbsp;nbsp;nbsp; 作者：Michael Hejnaa, Stefan Wamp;ouml;hrerb, Manuela Schmidingera, Markus Raderera,b 【关键词】nbsp; ,Gastric,cancer,amp;#8226;,Adjuvant,treatment,amp;#8226;,Chemotherapy,amp;#8226;,Review 　　LEARNING OBJECTIVESnbsp; 　　After completing this course, the reader will be able to: 　　Identify the current standard of care and new chemotherapy options for patients with resected gastric cancer. 　　Discuss recently reported results of phase II and phase III randomized trials of chemotherapy for the postoperative treatment of gastric cancer. 　　Discuss the clinical implications of recent clinical trial findings and future treatment strategies. 　　ABSTRACTnbsp; nbsp; 　　Introduction. Adjuvant chemotherapy for gastric cancer after potentially curative surgery has been under clinical investigation for more than four decades. However, potentially curative resection can be performed in only 30%50% of patients. The objective of this article is to review briefly the clinical trials available in the current literature using adjuvant cytotoxic chemotherapy in patients with gastric cancer after potentially curative surgical resection. 　　Methods. Computerized (MEDLINE) and manual searches were performed to identify papers published on this topic between 1965 and 2005. Only articles with an English abstract were reviewed for inclusion; information abstracted included histologic proof of diagnosis, number of patients, dose and modality of treatment, survival duration, and side effects. 　　Results. Forty-three reports were identified. Single-agent chemotherapy was evaluated in four clinical trials, and postoperative combination chemotherapy was evaluated in 33 trials. Furthermore, we identified five meta-analyses. Five-year survival rates ranged from 12%91.2%, and the median survival durations were 1360+ months. Adjuvant chemotherapy, when compared with surgery alone, seems to res