头颈肿瘤术后个体化放疗__培训课件.pptxVIP

头颈鳞癌个体化术后放疗复旦大学附属肿瘤医院放疗科朱国培2011-12-11FDUCC头颈多学科治疗组--放疗组2010年收治病例Diseases2010 YearOral Cavity50Oral Pharynx36Larynx60Hypopharynx30Nasal Cavity/Sinus7/18Nasopharynx865Thyroid/Salivary42/64Total1172219 例为术后病例头颈肿瘤的术后放疗---50多年的历史Am J Roentgenol Radium Ther Nucl Med 1957 Mar;77(3):397-414.Planned combination of surgery and radiation in treatment of advanced primary head and neck cancers.Maccomb, WS and Fletcher, GS手术与放疗的最佳联合模式Vandenbruck Cancer 1977 1445-1449N=49 随机55Gy/ 5.5 周5-yr 生存率 S + RT 56% RT + S 20%RTOG 73-03: 术前Vs术后 T3-4 可手术下咽/声门上喉癌 N=277 随机局控 S + RT (60 Gy) 56% RT+ S (50 Gy) 48% (p=0.04