内皮素的影响.docVIP

内皮素的影响 nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp; 作者：胡立新 张占英 李艳玲 云昀nbsp;nbsp;nbsp; 【摘 要】 目的nbsp; 观察抗衰保心汤对充血性心力衰竭（CHF）及血浆一氧化氮（NO）、内皮素（ET）的影响。 方法nbsp; 选择88例CHF患者，随机分为2组，对照组以西医常规治疗，治疗组在对照组治疗基础上口服抗衰保心汤，每日1剂，水煎取汁300mL，分2～3次服用。疗程均3周，观察疗效，并检测治疗前后血浆NO、ET水平变化。 结果nbsp; 治疗组总有效率、显效率分别为92.00%、54.00%，显著优于对照组73.68%、34.21%（P均lt;0.05）。2组治疗后与治疗前比较血浆NO及ET含量均明显降低（P均lt;0.01），且2组治疗后血浆NO及ET含量变化比较差异均有统计学意义（Plt;0.01）。 结论nbsp; 抗衰保心汤可改善CHF心功能，并有恢复NO与ET之间合成释放平衡的作用。 nbsp;nbsp;nbsp;nbsp; 　　【关键词】nbsp; 心力衰竭，充血性;一氧化氮;内皮缩血管肽类;中药疗法 nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp; 　　The effect of Kangshuaibaoxin decoction on NO and ET in blood plasma and patients with congestive heart failurenbsp;nbsp;nbsp;nbsp; 　　【Abstract】 Objective To observe the effect of Kangshuaibaoxin decoction on No and ET in blood plasma and pa-tients with congestive heart failure.Methods 88patients with congestive heart failure were randomly divided into control group，which was treated by routine therapy，and treatment group，which was treated by combination of routine therapy and Kangshuaibaoxin decoction（a dose of300mL every day）.The therapeutic course was3weeks in both groups.The changes of NO and ET in blood plasma were measured before and after treatment.Results The total effective rate and excellence rate in treatment group（92.00%，54.00%）were higher than those in control group（73.68%，34.21%，Plt;0.05）.The levels of NO and ET in blood plasma after treatment decreased compared with those before treatment in both groups（Plt;0.01）.There were significant differences of NO and ET between two groups after treatment（Plt;0.01）.Conclu-sion Kangshuaibaoxin decoction has a good effect on congestive heart failure，and adjust release of NO and ET. nbsp;nbsp;nbsp; 　　【Key words】 Kangshuaibaoxin decoction;Congestive heart failure;NO;Endothelin nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp; 　　充血性心力衰竭（congeseive heare failure，CHF）是各种心血管疾病晚期的共同结局，许多的研究资料表明，由血管内皮细胞生成的一氧化氮（NO）、内皮素（ET）等血管活性物质与CHF的发生关系密切，他们一起参与CHF的病