自擬肾炎方治疗慢性肾小球肾炎43例的临床观察和作用机制研究.docVIP

自拟肾炎方治疗慢性肾小球肾炎43例的临床观察和作用机制研究 Chinese Drug nephritis side treatment of 43 patients with chronic glomerulonephritis Clinical observation and mechanism study 华 琼 Hua Qiong （河南省中医药研究院附属医院肾病科，河南 郑州 450004） (Henan Academy of Traditional Chinese Medicine Hospital of Nephrology, Zhengzhou 450004) 摘 要 目的：通过观察自拟肾炎方对慢性肾小球肾炎的治疗效果，来探讨其作用机制，为慢性肾小球肾炎的临床治疗提供理论基础。方法:将86例慢性肾小球肾炎患者随机分为治疗组和对照组各43例，对照组采用西医常规治疗，治疗组在对照组基础上加服肾炎方，治疗8周后对两组临床治疗效果进行比较，并观察治疗前后两组尿常规、肾功能及血清转化生长因子（TGF-β1）、血浆血管内皮血管因子（VEGF）、血清免疫球蛋白（Ig）及补体3（C3）水平的变化。结果：治疗组总有效率95.3%，对照组总有效率81.3%，两组比较有显著性差异（P0.05）；两组均能显著降低尿红细胞、尿蛋白水平，改善肾功能，且治疗组优于对照组（P0.05或P0.01），两组均能显著降低血清TGF-β1、VEGF、IgA，提高IgG、IgM、C3水平，且治疗组优于对照组（P0.05或P0.01）。结论：利用中药肾炎方在治疗肾小球肾炎中疗效显著。可延缓肾衰病的发展进程。 Abstract: To observe the use of traditional Chinese medicine prescription, the effects of chronic glomerulonephritis, to explore its mechanism. For the clinical treatment of chronic glomerulonephritis provide a theoretical basis. Methods: 86 patients with chronic glomerulonephritis were randomly divided into treatment group and control group 43 patients in the control group treated with conventional Western medicine, the treatment group received additional services on the basis of traditional Chinese medicine prescription nephritis, treatment for 8 weeks clinical effect after the two groups were compared, and two groups of urine before and after treatment, renal function and serum transforming growth factor (TGF-β1), plasma vascular endothelial factor (VEGF), serum immunoglobulin (Ig) and complement 3 (C3) levels were observed. Results: The total effective rate of 95.3% in the control group, the total efficiency of 81.3%, compared the two groups was significant difference (P 0.05); significantly reduced in both groups of erythrocytes in urine, urine protein levels, improve renal function, and the treatment group than the control group (P 0.05 or P 0.01), both groups significantly decreased serum TGF-β1, VEGF, IgA, increased IgG, IgM, C3 levels, and the treatment group th