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SUCROSE HEMOLYSIS TEST Mr. Mohammed A. Jaber The sucrose hemolysis test is used as a confirmatory test for paroxysmal nocturnal hemoglobinuria (PNH) when the sugar water test is positive. Paroxysmal nocturnal haemoglobinuria (PNH) is an acquired clonal disorder of haemopoiesis in which the patients red cells are abnormally sensitive to lysis by normal constituents of plasma. Introduction It is characterized by haemoglobinuria during sleep (nocturnal haemoglobinuria), jaundice, and haemosiderinuria. PNH is an acquired clonal disorder resulting from a somatic mutation occurring in a haemopoiet