u v- v i s s p e c t r o p h o t o m e t r i c a s s a y o f m e t o p r o l o l(u v - v i s s p e c t r o p h o t o m e t r i c a s s a f m e t y o o p r o l o l).docVIP

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u v- v i s s p e c t r o p h o t o m e t r i c a s s a y o f m e t o p r o l o l(u v - v i s s p e c t r o p h o t o m e t r i c a s s a f m e t y o o p r o l o l).doc

u v- v i s s p e c t r o p h o t o m e t r i c a s s a y o f m e t o p r o l o l(u v - v i s s p e c t r o p h o t o m e t r i c a s s a f m e t y o o p r o l o l)

UV-VIS SPECTROPHOTOMETRIC ASSAY OF METOPROLOL. NOTE 2. METHOD VALIDATION MAGDALENA B?DULESCU1*, DAN B?L?L?U2, IOANA CACOVEAN2, MIHAELA ILIE2, DANIELA LUIZA BACONI2 1National Medicines Agency, 48 Aviator S?n?tescu Str., Bucharest 2”Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Toxicology Department, 6 Traian Vuia Str., Bucharest, Romania *corresponding author: magdalena.badulescu@anm.ro Abstract Metoprolol is a widely used beta-blocker mostly administrated in cardiovascular diseases. Due to the highly probable overdosage, a rapid and easy to perform method for the

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