钙离子阻滞剂报告.ppt

具有较强的扩张冠状动脉作用，在增加冠状动脉血流量的同时，通过使末梢血管阻力降低，从而减轻后负荷降低心肌耗氧量，增加心搏出量。 * 心脏作用：短效二氢吡啶类钙拮抗剂由于外周血管的扩张作用减低了心脏后负荷以及反射性的交感反射增强心肌收缩力，从而抵消了其负性肌力作用 血管平滑肌作用：第二代钙离子拮抗剂有较好的血管选择性，扩张冠状动脉，并改善侧支循环，对脑、肾、肠系膜及肢体血管也有舒张作用，在降压的同时还可改善重要脏器血流量 * * The benefits of a systolic blood pressure (BP) below 150-160 mmHg are well established; whether a systolic BP of less than 140 mmHg provides additional benefits remains controversial. This study was designed to compare the 2-year effect of a strict treatment to maintain systolic BP below 140 mmHg (group A) and that of a mild treatment to maintain systolic BP at between 140 and belo