chum和bley_spm2010_multipletesting.pptVIP

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2017-01-20 发布于福建
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chum和bley_spm2010_multipletesting.ppt

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LIKE THROWING A DICE. YOU CAN CONTROL THE FALSE POSITIVE RATE. * LIKE THROWING A DICE. YOU CAN CONTROL THE FALSE POSITIVE RATE. * LIKE THROWING A DICE. YOU CAN CONTROL THE FALSE POSITIVE RATE. * Deciding which distribution the data comes from (between two probability models) . * LIKE THROWING A DICE. YOU CAN CONTROL THE FALSE POSITIVE RATE. * LIKE THROWING A DICE. YOU CAN CONTROL THE FALSE POSITIVE RATE. * LIKE THROWING A DICE. YOU CAN CONTROL THE FALSE POSITIVE RATE. * Suprathreshold BLOBS not voxels, under the null Not really interested in infering voxels anyway * Two surprising features!Two thresholds! * Two surprising features!Two thresholds! * Two surprising features!Two thresholds! * Multiple testing Justin ChumbleyLaboratory for Social and Neural Systems Research Institute for Empirical Research in Economics University of Zurich With many thanks for slides images to: FIL Methods group Overview of SPM Realignment Smoothing Normalisation General linear model Statistical parametric map (SPM) Image time-series Parameter estimates Design matrix Template Kernel Gaussian field theory p 0.05 Statistical inference Inference at a single voxel t = contrast ofestimatedparameters varianceestimate t Inference at a single voxel H0 , H1: zero/non-zero activation t = contrast ofestimatedparameters varianceestimate t ? Inference at a single voxel Decision:H0 , H1: zero/non-zero activation t = contrast ofestimatedparameters varianceestimate t ? h Inference at a single voxel Decision:H0 , H1: zero/non-zero activation t = contrast ofestimatedparameters varianceestimate t ? h ? Inference at a single voxel Decision:H0 , H1: zero/non-zero activation t = contrast ofestimatedparameters varianceestimate t ? h Inference at a single voxel Decision:H0 , H1: zero/non-zero activation t = contrast ofestimatedparameters varianceestimate t ? h Decision rule (threshold) h, determines related error rates , Convention: Choose h to give acceptable