ImprovedMRITemperatureImagingUsingaSubject-Specific.pptVIP

Model Predictive Filtering Results Phantom Heating 2.0 x 2.0 x 2.0 mm 0.5 seconds per image 256 x 162 x 48 mm σT 1°C Transverse: Sagital: Coronal: Summary: Work in Progress Brain requires: Large FOV: Cover insonified volume High speed: 1s/volume High resolution: 1 x 1 x 3 mm3 Our solutions: PRF: Highly undersampled (8) 3D segmented EPI TCR: Does not require tissue thermal and acoustic properties Achieves high spatial and temporal resolution, large FOV, LOW NOISE! Cannot (yet) be performed in real time Model-predictive Filtering (MPF) Requires tissue segmentation estimate of tissue acoustic and thermal properties Property estimates: SAR: Hybrid Angular Spectrum (HAS) Diffusivity/Perfusion: MRI during cooling Also achieves high spatial and temporal resolution, large FOV, LOW NOISE! Potential real time application Parallel imaging Can be used to supplement TCR or MPF Difficult with currently used HIFU coils Acknowledgments Thank You Funding: Focused Ultrasound Surgery Foundation Siemens Medical Solutions NIH grants F31 EB007892-01A1, R01 EB013433, and R01 CA134599. * We appreciate the opportunity to present at this NCIGT workshop. During the past 10 years our involvement in MRI guided HIFU has increased and we currently have three functioning HIFU systems: Our original large animal * * For a typical HIFU heating, Another aspect to the grant is to improve the planning, monitoring and assessment of HIFU treatments. In this example Yi Wang has implemented a h-SVM algorithm to segment the breast into multiple tissue types. This segmentation aids both the thermometry and US modeling efforts needed to accurately plan a treatment. The algorithm requires five multi-parametric images as inputs to the algorithm. The results show that using the h-SVM algorithm after interpolating the data give a more accurate segmentation than c-SVM, FCM or h-SVM with no interpolation. This accuracy was confirmed both visually and statistically by a breast radiologist. * * *