ppt课件-structural alignmentof circularly permutated proteins（循环结构alignmentof更动蛋白质）.pptVIP

Order independent structural alignment of circularly permutated proteins T. Andrew Binkowski Bhaskar DasGupta? Jie Liang? Bioengineering Computer Science Bioengineering UIC UIC UIC  Circular Permutations Ligation of the N and C termini of a protein and a concurrent cleavage elsewhere in the chain Structurally similar, stable, and retain function Occur in nature: Tandem repeats via duplication of the C-terminal of one repeat with the N-terminal of the next repeat Transposable elements