Kinsela system biology.pptVIP

Systems Biology,Cancer Therapeutics,andPersonalized Medicine Timothy Kinsella, M.D.  搭咀吧负箕熔跨历葡疾苍皿湍糊嚷税扮能婆摄苏谬春幂篓捅兵持枷衍兜戍Kinsela system biologyKinsela system biology Systems biology is the analysis of the interactions among components of a biological system in response to genetic or environmental perturbations, with the goal of understanding the emergent properties of the system and its behavior. Towards Understanding Cancer Biology: Organized Complexity Cancer results from aberrations in the normal interactions of the component elements in the body in response to genetic or environmental perturbations. Understanding the disease requires understanding the emergent properties of the system. 忌容归坎屹男惭挝于囊刃揣戍绩掐盘佑蔬神棱陶际磷渺吐驼坍巾荚谆陆审Kinsela system biologyKinsela system biology Cancer: A Systems Biology Disease Genes and genetics Complex signaling networks Multiple cellular processes Micro-environment Host systems Environmental factors Population dynamics Initiation Progression Metastasis Recurrence Time - Progression Histology Variation 菠扔血绚割笑丰扫列酱狐捂葛惊耀蛊丈九蛀周你爵己溶增寅秩泉呼健湾订Kinsela system biologyKinsela system biology Develop an integrative approach to the understanding of cancer through the development of multidisciplinary research teams Create predictive in-silico models to aid with the understanding and management of the disease Integrate and explore the multi-dimensionality of large “omic” datasets as well as quantitative and descriptive data. Enrich the community and the developing field through shared resources and a vibrant educational/outreach effort. Goals of the ICBP 侨甸脊赐配嗽润励瑰符够列泻揣生与殴减雕驾吓蓝通闷缕息糯呀棕证单沿Kinsela system biologyKinsela system biology Integrative Cancer Biology Program Huang (OSU) - epigenetics, gene silencing Golub (DFCI) - kinase, signaling, high throughput biology Kinsella (CWRU/UHC) - DNA repair, drug/radiation effects, therapy (MIT) – signaling, mouse models, mitogenesis, DNA repair, progression Nevins (Duke) – signaling networks, cell fate, proli