ppt课件-absorption spectroscopy protein function（吸收光谱蛋白质功能）.pptVIP

Absorption Spectroscopy/Protein Function Topic 4 Part 2 Biophysics Chemical KineticsZero Order Rate independent of concentrations -dC/dt = k C(t) = C0 – kt Chemical KineticsFirst Order -dCA/dt = kCA , CA = CA0 e-kt t1/2 = ln(2)/k; t = 1/k = lifetime Chemical KineticsSecond Order -dCA/dt = -dCB/dt = kCACB Make one species in excess so get pseudofirst order kinetics, kobs = kCB so CA = CA0 exp(-kobst) Hemoglobin On the Nature of Allosteric Transitions:A Plausible Model Jacques Monod, Jeffries Wyman, Jean-Pierre Changux J. Mol. Biol. 1965 “Molecular Amplifiers” ATCa