冠心病感染因子的血清学研究.docVIP

冠心病感染因子的血清学研究 　　作者：唐 林 　　作者单位： 300070 天津，天津医科大学免疫教研室 　　【摘要】 目的 了解冠心病、动脉硬化患者的感染因子。对84例冠心病患者进行研究，其中包括急性心肌梗死(AMI)、不稳定型心绞痛(UAP)和稳定型心绞痛(SAP)患者。方法 应用酶免疫法测定患者血清中抗肺炎衣原体(Cpn)的IgM和IgG型抗体、抗幽门螺杆菌(Hp)的IgM和IgG型抗体、抗巨细胞病毒(CMV)的IgM型抗体。并与健康对照组进行比较。结果 AMI组Cpn和Hp感染高于健康对照组(Cpn IgG：P0.05;Hp IgM：P0.05;Hp IgG：P0.01)。CMV感染率与健康对照组比较差异无显著性。UAP组Cpn和Hp感染率高于健康对照组(Cpn IgG：P0.05;Hp IgG：P0.05)。CMV感染率与健康对照组比较差异无显著性。SAP组Cpn和Hp感染率高于健康对照组(Cpn IgG：P0.05;Hp IgM：P0.05;Hp IgG：P0.005)。CMV感染率与健康对照组比较差异无显著性。AMI组、UAP组和SAP组对各感染因子的感染率差异无显著性(P0.05)。结论 研究表明Cpn和Hp作为冠心病患者的感染因子，其联系较为明显。而CMV是否为冠心病患者的感染因子还有待于进一步研究。 　　【关键词】 冠心病;肺炎衣原体;幽门螺杆菌;巨细胞病毒 　　Study on infection factors of coronary heart disease 　　TANG Lin. 　　Tianjin Medical University,Tianjin 300070,China 　　【Abstract】 Objective To study the infection factors of patients with coronary heart disease(CHD) and atherosclerosis.Methods Serum of 84 patients were studied.Among them are cases of acute myocardial infarction(AMI),unstable angina pectoris (UAP) and stable angina pectoris(SAP).Compared with the control groups,the sera were analysed for the presense of antibodies by ELISA.These antibodies included chlamydia pneumoniae (Cpn)-specific IgM and IgG antibodies,Helicobactor pylori (Hp)-specific IgM and IgG antibodies and cytomegalovirus(CMV)-specific IgG antibodies.Results Serological prevalences of Cpn and Hp infection were significantly higher in patients than in control subjects while that of CMV infection had no differences in patients and control subjects.The prevalences of the three groups(AMI,UAP,SAP) by the three infection factors(Cpn,Hp,CMV) had no differences in each other.Conclusion As the infection factors to develop CHD,Cpn and Hp have more significance than CMV.To determine whether CMV is a infection factor of CHD,more studies will be performed. 　　【Key words】 coronary heart disease;chlamydia pneumoniae;Helicobactor pylori;cytomegalovirus 　　冠心病(冠状动脉粥样硬化性心脏病，CHD)是指冠状动脉粥样硬化使血管腔阻塞导致心肌缺血缺氧而引起的心脏病[1]。根据冠状动脉病变的部位、范围、血管阻塞率和