动脉粥样硬化研究进展.ppt

Clinical practice: One interesting target might be malondialdehyde-(MDA,丙二醛)-modified ApoB100 p45 peptide, as immunization with this peptide triggered the generation of reactive antibodies of the IgG class. Inducing ox-LDL removal and interfering with pro-inflammatory effects against ox-LDL in particular leukocytes such as monocytes and neutrophils, actively participates in thrombus formation at many stages During arterial thrombosis, activated platelets of the growing clot release chemokines and express adhesion molecules such as P-selectin, causing subsequent recruitment of monocytes and neutrophils into the growing thrombus Activated platelets form aggregates with monocytes that express the ligand for P-selectin, namely P-selectin glycoprotein ligand-1 (PSGL-1). These monocyte-platelet aggregates (MPA) were shown to be elevated in patients with unstable angina, acute myocardial infarction and after coronary intervention in stable patients The classical notion of TF as a mere subendothelial protein has been challenged by the detection of TF-expressing monocytes within the blood stream Intra-vascular TF and TF within atherosclerotic plaques may represent the main trigger of atherothrombosis following plaque rupture Exhibits pro-inflammatory effects by activating PAR-receptors that are expressed by cells throughout the atherosclerotic lesion Direct thrombin inhibition with melagatran and dabigatran reduced plaque formation, promoted plaque stability and improved endothelial function in ApoE-/- mice adipose tissue is a major endocrine and paracrine organ producing numerous enzymes, hormones and growth factors which are collectively termed as adipokines e.g. adiponectin, leptin, resistin,tumor necrosis factor-alpha (TNF-a), interleukin-6 (IL-6), plasminogen activator inhibitor-1 (PAI-1), atrial natriuretic peptide and angiotensinogen Modulate insulin sensitivity, glucose/fat metabolism and obesity Several direct actions of adipokines on endothelial function, v