Effect of Oryzanol and Ferulic Acid on the Glucose Metabolism of Mice Fed with a HighFat Diet.docVIP

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2017-02-13 发布于江苏
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Effect of Oryzanol and Ferulic Acid on the Glucose Metabolism of Mice Fed with a HighFat Diet.doc

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Effect of Oryzanol and Ferulic Acid on the Glucose Metabolism of Mice Fed with a High-Fat Diet 谷维素和阿魏酸对喂食高脂食物小鼠葡萄糖代谢的影响 Myoung Jin Son, Catherine W. Rico, Seok Hyun Nam, and Mi Young Kang Abstract: The effects of oryzanol and ferulic acid on the glucose metabolism of high-fat-fed mice were investigated. 本实验探究了谷维素和阿魏酸对膳食高脂肪食物小鼠葡萄糖代谢的影响。Male C57BL/6N mice were randomly divided into 4 groups: NC group fed with normal control diet; HF group fed with high-fat (17%) diet; HF-O group fed with high-fat diet supplemented with 0.5% oryzanol; and HF-FA group fed with high-fat diet supplemented with 0.5% ferulic acid. C57BL/6N 型小鼠被随机分为4组，NC 组喂食正常饮食，HF 组喂食高脂膳食，HF-O组和HF-FA组喂食高脂膳食同时在饲料分别加谷维素和阿魏酸。All animals were allowed free access to the experimental diets and water for 7 wk. 所有老鼠可以自由取食取水。At the end of the experimental period, the HF-O and HF-FA groups exhibited significantly lower blood glucose level and glucose-6-phosphatase (G6pase) and phosphoenolpyruvate carboxykinase (PEPCK) activities, and higher glycogen and insulin concentrations and glucokinase (GK) activity compared with NC and HF groups. 经测量实验结束后，HF-O组和HF-FA组比NC组和HF组小鼠血糖水平、G6pas、 PEPCK活性显著降低，而糖原、胰岛素浓度以及GK活性显著降低。The results of this study illustrate that both oryzanol and ferulic acid could reduce the risk of high-fat diet-induced hyperglycemia via regulation of insulin secretion and hepatic glucose-regulating enzyme activities. 此研究表明谷维素和阿魏酸能减少胰岛素和控制一些酶的活性。 Keywords: diabetes,糖尿病 ferulic acid, 阿魏酸high-fat-fed mice,高脂肪喂食小鼠 hypoglycemic effect, 降血糖功能oryzanol谷维素 Introduction Chronic consumption of a high-fat diet has been associated with the development of obesity and type 2 diabetes mellitus (Hill and others 1992; Bray and others 2004).长期食用高脂肪食品与肥胖和二型糖尿病的产生密切相关。Scientific studies have shown that excessive intake of dietary fat results in increased body weight and poor glucose regulation (Alsaif and Duwaihy2004; Petro and others 2004; Messier and others 2007). 科学研究表明脂肪的过多摄入导致肥胖并影响血糖调节。Diabetes is characterized by hypergl