Effects of Exercise Following Lateral Fluid Percussion Brain侧流冲击脑运动的影响.ppt

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2017-02-13 发布于上海
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Effects of Exercise Following Lateral Fluid Percussion Brain侧流冲击脑运动的影响.ppt

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Introduction to Neurotrophin Include: Nerve Growth Factor (NGF) Brain-Derived Neurotrophic Factor (BDNF) Neurotrophin T-3 and NT-4 Receptors: Low Affinity: p75 High Affinity: TrkA, TrkB, and TrkC In development: Regulates neuronal innervation to specific targets In adults: Regulates neuronal plasticity Regulates the number of neuronal progenitor cells Effects of Exercise Following Lateral Fluid Percussion Brain Injury in Rats Romana R. Hicks, et al. University of Kentuky Restorative Neurology and Neuroscience 12 (1998) 41-46 Background After brain injury?many impairments Exercise has shown to: Maybe maintain memory: increases 5HT and noradrenaline With PreTx of Exc: attenuates ischemic damage Activate different molecular cascades: increase of EC lactate, increases antioxidant enzymes, and increases BDNF, NGF, and bFGF Hypothesis “…tested whether exercise following a lateral fluid percussion (FP) brain injury could increase BDNF mRNA expression in the hippocampus and attenuate the neuropathology and behavioral deficits that are associated with this model of experimental brain injury in rats.” Materials and Methods Surgery: Sprague-Dawley rats, n=20 Utilizing the stereotaxic and FP device placed a unilateral brain injury to the left parieto-occipital cortex Materials and Methods, cont Treadmill Training: Began the day after FP injury (n=10) with 5min Time increased 5min per day until 60min reached Control (n=9): Handled 30-60sec daily Behavioral Tasks MWM: day15-17 post-op ? after 12 trials, 90sec probe Inclined plane test Visual Limb Placing Vertical Righting Response Grip Test Materials and Methods, cont In Situ Hybridization: Three sections from dorsal hippocampus were analyzed per animal Results Results Discussion Exercise after FP injury does not: Attenuate histological, cognitive, or neuromotor deficits (were there any deficits?) Exercise after FP injury does: Increase hippocampal BDNF mRNA compared to injured/no exercise group Discussion cont Suggestions