不同剂量阿斯匹林抑制血小板聚集功能时效探讨.docxVIP

不同剂量阿斯匹林抑制血小板聚集功能时效探讨作者：admin ?? 发布于：2014-10-10不同剂量阿斯匹林抑制血小板聚集功能时效探讨中华医学检验杂志 1998 年第5 期第21 卷 *论著*作者：丛玉隆张岩殷宗健邓新立单位：100853 北京，解放军总医院临检科关键词：血小板聚集试验；阿斯匹林【摘要】目的探讨阿斯匹林常用剂量下，血小板聚集率的变化规律及诱导剂的选择。方法 30 名经体检健康的自愿者，随机分为3 组。第一组一次服用200 mg 阿斯匹林，第二组初服100 mg 阿斯匹林后每日50 mg 追加量，连服7 天。第三组口服50 mg 阿斯匹林。各组分别在不同时间进行采样，样本用花生四烯酸、瑞斯托霉素、胶原、二磷酸腺苷(ADP)四种诱导剂进行血小板聚集实验。结果第一组停药第7 天，血小板聚集率恢复到服药前水平。花生四烯酸诱导的血小板聚集实验对口服阿斯匹林最为敏感。第二组，血小板聚集率在服药的7 天及停药后9 天内与用药前差异有非常显著意义(P＜0.01)，在第10 天差异有显著意义(P＜0.05)，第11 天恢复至服药前水平。以上两组，花生四烯酸诱导的血小板聚集率的变化比其他诱导剂诱导的变化明显。第三组3 天内血小板功能仍受明显抑制。结论首服剂量越大，维持服药的时间越长，血小板聚集功能恢复所需时间越长。花生四烯酸诱导的血小板聚集实验是监测阿斯匹林剂量比较理想的实验。The Dynamic Changes of Platelet Aggregation In Treatment of Aspirin Congyulong, Zhang Yan, Yin Zongjian, et al. Deng Xinli PLA General Hospital, Beijing100853【Abstract】 Objective Approach of the dynamic changes of platelet aggregationin treatment of aspirin.Methods Three groups (A, B and C) of volunteers were givendifferent dose of aspirin: 200 mg were given only day on A group (n=10); B group(n=10), 100 mg in the first day, then 50 mg/day in 7 days; 50 mg were given onlyday on C group (n=10). Platelet-rich plasma were obtained in planed days: A group,every day for 7 days after oral aspirin treatment; B group, in the 4th and 7th dayafter oral aspirin treatment, and the 6th, 8th, 10th and 11th day after finishingoral aspirin treatment; C group, in 2h, 24h, 48h, 72h after oral aspirin treatment.Then platelet aggregation induced by ADP, collagen, ristocetin and arachidonic acidwere examined.Result A group, platelet aggregation restored in the 7th day afterfinishing oral aspirin treatment; B group, in the 18th day after finishing oralaspirin treatment; C group, not restored in the 3rd day after finishing oral aspirintreatment yet. In oral aspirin treatment, there were more sensitive change inplatelet aggregation induced by arachidonic acid than other inductor.ConclusionThat aspirin inhibit platelet aggregation was relation with dose and the durationof oral aspirin therapy. The platele