美沙拉嗪缓释颗粒对溃疡性结肠炎患者血清IL6TNFα影响机制的研究.docVIP

美沙拉嗪缓释颗粒对溃疡性结肠炎患者血清IL-6、TNF-α影响机制的研究 [摘要] 目的 探讨美沙拉嗪缓释颗粒对溃疡性结肠炎患者的疗效，以及对血清白介素（il-6）、肿瘤坏死因子（tnf-α）影响机制的研究。方法 入院确诊的70例溃疡性结肠炎患者随机分为治疗组（美沙拉嗪缓释颗粒）和对照组（sasp）各35例，比较两组治疗前后肠镜变化、临床疗效及血清il-6、tnf-α的变化情况。结果 治疗组的疗效优于对照组（p＜0.01）。两组治疗后的il-6、tnf-α较治疗前明显降低，p＜0.01，t值分别为12.36，12.75，12.24，12.42，且治疗组的降低程度较对照组更明显，差异有统计学意义，t值分别为12.27，12.35，p＜0.01。 结论 美沙拉嗪缓释颗粒治疗溃疡性结肠炎可显著提高临床疗效，考虑可能是通过降低il-6水平、tnf-α而起作用的，其具体机制尚有待进一步研究。 [关键词] 溃疡性结肠炎；美沙拉嗪缓释颗粒；血清白介素（il-6）；肿瘤坏死因子（tnf-α） [中图分类号] r574.1 [文献标识码] b [文章编号] 1673-9701（2011）36-34-02 the study of the mechanism of mesalazine release granules on serum il-6，tnf-α in ulcerative colitis patients chen qiangmei zhejiang province tonglu country mch，tonglu 311500，china [abstract] objective to investigate the efficacy of mesalazine on the of ulcerative colitis，and to explore the mechanism of serum interleukin（il-6）， tumor necrosis factor（tnf-α） in uc. methods all of 70 patients with ulcerative colitis were randomly divided into treatment groups（mesalazine slow-release granules） and the control group（sasp） two groups，each 35 cases，endoscopic changes and clinical efficacy and serum il-6，tnf-α changes were compared before and after treatment. results the efficacy of the treatment group was better than the control group（p＜0.01）. after treatment， the levels of il-6 was significantly lower than before treatment，the treatment group decreased level of serum il-6 was more significantly than the control group， the difference was statistically significant，p＜0.01. conclusion mesalazine slowes release granules for ulcerative colitis，and it can significantly improve the clinical efficacy，consideration may be by reducing the level of il-6 play a role，the specific mechanism remains to be further studied. [key words] ulcerative colitis；mesalazine slow release granules；serum interleukin（il-6）；tumor necrosis factor（tnf-α） 溃疡性结肠炎是消化系的常见病、多发病，近年来，其发病率逐年升高，目前临床治疗溃疡性结肠炎的方法较多，且疗效报道不一[1]。研究发现，白介素（il）在溃疡性结肠炎（uc）的发病中起了重要作用，其中il-6分泌增加影响肠上皮细胞电解质分泌紊乱，介导了其他炎性细胞发生炎性反应[2