性激素水平与血管性痴呆发病关系.docVIP

404139 作者修改稿 发件人：杨晓妮?yangxiaoni1979@163.com2014年6月20日 16:17 (星期五) 收件人：zgyy8888?zgyy8888@163.com yangxiaoni1979@163.com 通信作者：李长E-mail：lifs8656@163.com。 [摘要] 目的 探讨中药首乌益智胶囊对血管性认知障碍模型大鼠脑组织海马神经元超微结构的影响。方法 血管性认知障碍大脑中动脉法药物干预，透镜观察假手术组海马细胞核清晰可辨，核内细胞器丰富且结构清晰海马锥体细 胞缺失、线粒体肿胀、脑复康组海马区神经细胞核膜结构较清晰，线粒体絮状变，髓鞘结构较清晰，与模型组相比明显改善锥体细胞缺失减少，细胞器基本正常、血管周围水肿减轻。结论 首乌益智胶囊能明显改善VCI大鼠神经元的损伤。 [关键词] VCI；首乌益智胶囊；电镜；超微结构；动物实验 [中图分类号] R277.7 [文献标识码] A Effect of Shouwuyizhi Capsule on the ultrastructure of brain tissue Vascular Dementia Model Rats YANG Xiao-ni.Qianfoshan Hospital of Shandong Province,Jinan(250014) [Abstract] Objective To investigate the effect of Shouwuyizhi (SWYZ) capsule on the ultrastructure of brain tissue in experimental rats with vascular cognitive impairment (VCI). Methods The VCI model rats were established with MCAO method.All the experimental rats were divided into the Shouwuyizhi group, the Naofukang group group, the model group and the sham operation group. After 4 weeks’medication, the rats’cerebral histomorphological change was observed by transmission light microscope. Results In the Sham operation group of 10 rats showed that the nucleus of hippocampal neurons are clear, organelles are abundant and have clear structure in nucleus; The model group with 9 rats showed that hippocampal pyramidal cells are obviously missed, mitochondrial are swelled and perivascular edema; in the Naofukang group with 7 rats showed that, hippocampus nerve cell membrane structure are relatively clear, some mitochondria flocculent degeneration, myelin structure are clear; in the Shouwuyizhi group with 9 rats showed that, the loss of pyramidal cells reduced, organelles basically normal, perivascular edema significantly relived, and compared with the model group significantly improved.Conclusion SWYZ capsule can significantly improve the VCI rat neuronal injury. [Key words] Shouwuyizhi capsule ; VCI; t