促性腺激素释放激素激动剂对子宫内膜异位症术后复发和生活质量的影响.docVIP

促性腺激素释放激素激动剂对子宫内膜异位症术后复发和生活质量的影响 　　（萍乡矿业集团总医院妇产科 萍乡 337042） 　　摘 要 目的：探讨促性腺激素释放激素激动剂（GnRHa）对子宫内膜异位症术后复发和生活质量的影响。方法：将2010年1月至2012年1月期间我院收治的子宫内膜异位症患者82例按数字随机法分为观察组和对照组，每组患者41例。对照组接受常规的子宫内膜异位手术及术后抗感染治疗，观察组在对照组的基础上于术后月经来潮第2天皮下注射曲普瑞林（3.75 mg，每28天1次，共治疗3次）。比较两组疗效、复发情况以及生活质量。结果：观察组疗效显著的患者比例和治疗有效率分别为58.54%和97.56%，均显著高于对照组。观察组治疗后6个月、1年和2年的复发率分别为2.44%、2.44%和4.88%，均显著低于对照组。两组治疗后躯体功能和社会功能2个维度和11个因子的生活质量评分得分均提高，且观察组得分较对照组提高。差异都有统计学意义。结论：GnRHa用于子宫内膜异位症术后辅助治疗疗效显著，可有效减少术后复发，并提高患者的生活质量，值得临床推广使用。 　　关键词 促性腺激素释放激素激动剂 子宫内膜异位症 术后复发 生活质量 　　中图分类号：R977.12； R711.71 文献标识码：B 文章编号：1006-1533（2014）17-0020-03 　　Influence of gonadotropin-releasing hormone agonist 　　on recurrence and life quality of endometriosis patients* 　　HE Xi** 　　（Department of Gynaecology and Obstetrics， General Hospital of Pingxiang Mining Group， Pingxiang 337042， China） 　　ABSTRACT Objective： To explore the influence of gonadotropin-releasing hormone agonist （GnRHa） on recurrence and life quality of endometriosis patients. Methods： Eighty-two endometriosis patients in our hospital from January 2010 to January 2012 were divided into an observation group and a control group with 41 cases each by digital randomized method. Both groups were treated by conventional endometriosis surgery and postoperative anti-infection therapy， and in addition， the observation group was treated by triptorelin （ih， 3.75 mg， once every 28 days for 3 times） in the second day of menstruation after the surgery. The efficacy， recurrence and life quality were compared between two groups. Results： The proportion of patients with obvious efficacy was 58.54% and the treatment efficiency is 97.56% in the observation group， which were both significantly higher than those in the control group. Recurrence rates of 6 months， 1 year and 2 years after the surgery in the observation group were 2.44%， 2.44% and 4.88%， respectively， which were lower than those in the control group. Life quality score in the two groups were improved after treatment， and wa