坤泰胶囊治疗不孕症100例疗效分析.docVIP

坤泰胶囊治疗不孕症100例疗效分析 　　doi：10.3969/j.issn.1007-614x.2014.16.58 　　摘 要 目的：探究坤泰胶囊治疗不孕症患者的临床用药机制及疗效，为提高不孕患者的受孕几率寻求有效的治疗方法。方法：2010年1月-2013年1月收治不孕症患者100例，所有患者均于第3个月经周期的第5天开始口服坤泰胶囊。观察治疗前后患者的子宫内膜厚度及形态，子宫内膜螺旋动脉血流参数搏动指数（PI）及阻力指数（RI）。结果：患者经治疗后子宫内膜厚度、PI值、RI值变化相比治疗前分别为t=8.3481（P=0.0000）、t=8.2067（P=0.0000）、t=19.2055（P=0.0000）；治疗后A型内膜相比治疗前χ2=13.2667（P=0.0003），差异具有统计学意义。结论：坤泰胶囊能有效改善患者的子宫内膜容受性，利于患者进行胚胎着床，从而提高患者的受孕几率，治疗不孕安全有效，值得临床推广使用。 　　关键词 坤泰胶囊 不孕症 用药机制 疗效 　　Analysis of the mechanism of kuntai in treatment of 100 cases with infertility 　　Liang Ying 　　Department of Reproductive Center，the Maternal and Child Hospital of Changsha City，Hunan 410007 　　Abstract Objective：To investigate the clinical effect and the mechanism of kuntai capsule in treatment of infertility patients，in order to find out an effective methods to improve the chance of pregnancy for infertility patients.Methods：100 cases with infertility were selected from January 2010 to January 2013.All cases were began to oral kuntai capsule at the fifth day of third menstrual cycle.We observed the endometrial thickness and morphology，uterine blood flow parameters of endometrial spiral artery pulsatility index（PI） and resistance index（RI） in patients before and after treatment.Results：Comparied the changes of endometrial thickness，PI value，RI value before and after the treatment，the result were t=8.3481（P=0.0000），t=8.2067（P=0.0000），t=19.2055（P=0.0000） respectively.Comparison result of type endometrium before and after treatment was χ2=13.2667（P=0.0003）.The difference was statistically significant.Conclusion：Kuntai capsule can effectively improve uterine receptivity，and helpful for embryo implantation，so it can improve the chance of pregnancy，and also safety and effectivly in treatment of infertility，so it is worth to be widely used in clinical. 　　Key words Kuntai capsule；Infertility；The mechanism of drug；Treatment effect 　　人类辅助生殖技术是一种根据医学技术手段方法，通过人工操作将精子、卵子、受精卵或是胚胎进行结合、着床以达到受孕的目的。既往研究表明[1]，胚胎着床的过程中会出现一个短暂的窗口期，在此期间，其着床