6.7.第2信使的信号通路.pptVIP

NO-cGMP-PKG 通路 开放钾离子通道 关闭钙离子通道 抑制内质网释放钙 PKG使MLC去磷酸化 血管平滑肌细胞舒张的典型过程 University of California-Los Angeles State University of New York in Brooklyn University of Texas Medical School in Houston. 1998 Nobel Prize Winners in Physiology or Medicine : Nobel prize committee say Yes to NO! cGMP及其激酶在心肌肥大中的作用 Nature Reviews Drug Discovery 6, 617-635 (2007) ;关注某个疾病发生发展时信号转导的变化。 cAMP和cGMP通路的关系 二者在生理效应上有一定的拮抗关系 ＋ PDE-3 AMP PDE有多种型号，分别对cAMP和cGMP特异。 Diagram illustrating possible interactions between angiotensin II- and guanylyl cyclase-dependent systems in the rat podocytes. NPR-A - guanylyl cyclase-link