凹凸棒复合氯消毒剂消毒效果研究和安全性评价.doc

凹凸棒复合氯消毒剂消毒效果研究和安全性评价 王建云 颜晓霞1* 梁剑平2 贾忠1 （1.兰州市肺科医院 730046；2. 中国农科院兰州畜牧与兽药研究所） 摘 要 目的：观察凹凸棒复合氯消毒剂的消毒效果和安全性。方法：将凹凸棒复合氯消毒剂和强力消毒灵按照不同的稀释度稀释后，与金黄色葡萄球菌、大肠杆菌、鼠伤寒沙门氏菌、蜡样芽孢杆菌、禽巴氏杆菌、丝状霉形体山羊亚种、鸡新城疫病毒、猪瘟病毒兔化弱毒分别作用不同时间，进行抑菌、杀毒效果的检测。通过急性经口毒性试验、皮肤刺激性试验和急性眼刺激试验评价该消毒剂的安全性。结果：凹凸棒复合氯消毒剂在不同稀释倍数下对细菌和病毒有一定的抑制和杀灭作用，且无明显毒性。结论：凹凸棒复合氯消毒剂安全、有效。 关键词：消毒剂；抑菌作用；杀毒作用；安全性 Reseach on Disinfection Effect and Security of Attapulgite Complicated with Chlorine Disinfectant Wang Jianyun1 Yan Xiaoxia1* Liang Jianping2 Jia Zhong1 1. Pulmonary Hospital of Lanzhou 730046 2.LanZhou institute of husbandry and pharmaceutical sciences of CAAS Abstract Objective To observe the disinfection effect and security of attapulgite complicated with chlorine disinfectant. Method The minimum inhibitory concentration and destroying effects of attapulgite complicated with chlorine disinfectant and QiangLi disinfectant were determined in different strains including Strphylocoocus aureus, Esherichia, Salmonella Iypimorium, Bacillus Cereus, Pasteurella auicida, Mycoplasma caprl, Newcastle disease virus (NDV) and Hog cholera lapinized virus (HCV). The security of this antiseptic was analyzed by acute oral toxicity test, skin hypersensitive test and irritant?effect on eye. Results Attapulgite complicated with chlorine disinfectant showed significantly bacteriostatic effects and disinfect effects on bacteria and virus strains in gradient dilute concentrations. Meanwhile, this antiseptic displayed little toxicity in all animal experiments. Conclusion Attapulgite complicated with chlorine disinfectant was safe and efficacious. Key words: disinfectant; bacteriostatic effects; disinfect effects; security 含氯消毒剂是世界上最早使用的化学消毒剂之一，是一种遇水时产生次氯酸的消毒剂，其有效成分常以有效氯表示。含氯消毒剂杀菌谱广, 合成工艺简单, 价格低廉, 毒性低, 在减少病原微生物污染, 防止感染有重要作用, 故也是目前应用最广泛的消毒剂之一。它具有杀菌效果可靠、价格低廉、使用方便等特点，几乎可以杀灭所有类型的微生物，甚至包括某些细菌芽孢和病毒。但含氯消毒剂也有其自身的弱点，它的杀菌性能易受到有机物及酸碱度的影响，对物品有一定的腐蚀作用，有些含氯消毒剂（如二氧化氯等）不够稳定，容易分解，消毒剂还能与体系中的芳香族化合物反应生成剧毒的物质。且多数含氯消毒剂及其复方制剂存在明显氯刺激性气味，对金属具腐蚀性, 液体制剂不稳定性等不足, 限制