金纳米颗粒题库.ppt

金标准溶液 从金纳米库了解纳米生化界面性质 theme Nanomaterials—quantum size effects Application: biochemical sensor, contrast agents in celluar or tissue imaging, drug delivery vehicles or as therapeutics This Account will focus on the use of GNPs both as probes to understand the interface of nanoparticles with biological systems and as models to study the impact of nanoparticle parameters on biological systems The Golden Timeline Reasons for a “Gold” Standard #3. #2. GNPs possess properties that make them relatively easy to quantify, locate and image in biological systems. GNPs are ideal nanomaterials to serve as probes for investigating the influence of nanoparticle size, shape, and surface chemistry on their biological interactions. synthesis The Characteristic of GNPs Spherical GNPs possess an intense Plasmon absorption that can be tuned over a limited spectral range(520-580nm) GNR solutions possess two Plasmon bands, a transverse Plasmon ban corresponding to light absorption and scattering along the short axis of the material(λmax~ 520nm), and an aspect ratio-dependent longitudinal plasmon band(λmax~600-1800nm) Cellular Uptake GNP uptake is quantified using a combination of ultraviolet-visible absorbance spectroscopy(ICP-MS). ICP-MS is a very sensitive analytical technique for gold, capable of detecting 60 parts per trillion gold atoms depending on their size. TEM visualizes GNRs within the cell following uptake. Cellular toxity