解热镇痛抗炎药解热作用.ppt

解热镇痛抗炎药ANTIPYRETIC ANALGESIC ANDANTI-INFLAMMATOGY DRUDS 北京协和医学院基础医学院药理学系 叶菜英 解热镇痛抗炎药 解热作用 Antipyretil action 解热镇痛抗炎药Antipyretic analgesic and anti –inflammatory drugs 解热作用 Antipyretil action Febrile:endogenous pyrogen →CNS →release PG↑ →thermotaxic center → Febrile Antipyretil ：inhibit PG synthetase，decrease synthesis of PG →hypothermy 解热镇痛抗炎药Antipyretic analgesic and anti –inflammatory drugs 镇痛作用 analgesic action depression bradykinin pain sensor antipyretic analgesic painstimulus PG