几种重要的信号转导通路_生物学_自然科学_专业资料.pptVIP

Dsnx3 interacts with Dwls in S2 cells Mutiple alignment of Snx3 homologue genes PtdIns3P binding motif PtdIns3P binding site is essential for Dsnx3 function UAS-SNX12-EGFP Merge In the absence of dVps35 activity: Wg protein is accumulated inside Wg-producing cells, but reduced on the cell surface of Wg-producing cells and in surrounding Wg-recieving cells. Wg protein levels are reduced in conditioned medium. Conclusion: Retromer is required for Wg secretion. Question: How Does Retromer regulate Wg secretion ? Similarity between dvps35 and Wls mutants B A Wg GFP E-cad merge B