IronMechanismsofPro-oxidantBehavior,CellularUptake,.pptVIP

Iron: Mechanisms of Pro-oxidant Behavior, Cellular Uptake, and Organism Survival Skills Bradley E. Britigan, M.D. Department of Internal Medicine VA Medical Center- Iowa City and Roy G. and Lucille A Carver College of Medicine University of Iowa Iron Can Contribute Directly or Indirectly to the Oxidation of : Proteins Lipids DNA Sugars Site-specific Oxidation ? Human Iron Metabolism Iron exists in 2+ (ferrous) or 3+ (ferric) state Little Free Iron in vivo Chelated to Proteins or Other Molecules Maintains Solubility Limits Participation in Oxygen Redox Chemistry Limits Availability to Microbes