血浆脂联素.docVIP

血浆脂联素与2 型糖尿病及其大血管病变相关性研究 张新焕 黄东辉 程厚文 王焕云 宋晓 （泰山医学院附属医院内分泌科 山东 泰安 271000） (电话E-mail: kathy0418 @ 163.com) 摘要：目的探讨血浆脂联素（adiponectin）在2 型糖尿病中的作用及相关性。方法 符合1999 年WHO 糖尿病诊断标准的2 型糖尿病（T2DM）患者6 例为糖尿病组。对空腹血糖（FPG）、血总胆固醇（TC）、甘油三酯（TG）、空腹胰岛素（FINS）体重指数（BMI）胰岛素敏感指数（ISI）血浆脂联素，并对结果 与对照组比较，2 型糖尿病患者空腹血糖（FPG）、总胆固醇（TC）、甘油三酯（TG）和FINS、BMIHbA1c水平明显高于对照组（P 0.0P 0.01），血浆脂联素水平明显低于对照组（P0.01）。（P0.01）2 型糖尿病病人血浆脂联素水平与、FPG、TC、TG、BMI显著负相关，与ISI 呈显著正相关结论 血浆脂联素在2 型糖尿病发挥保护性作用关键词： 2型糖尿病 脂联素The role and relationship of plasma adiponectin in the type 2 diabetes mellitus patients and macrovascular artherosclerosis. （Zhang Xin Huan,Huang DongHui,Cheng HouWen, Wang HuanYun, Song Xiao）affiliated hospital of tai shan medical colledge, Province shandong City Taian 271000, China; Telephone: E-mail: kathy0418 @ 163.com) ABSTRACT: Objective :To explore the role of plasma adiponectin in the type 2 diabetes mellitus patients and macrovascular artherosclerosis. Methods:In a cross sectional study, All subjects randomly recruited in were divided into group one(type 2 diabetes with artherosclerosis ), group two (type 2 diabetes without artherosclerosis) and normal control group. We measured adiponectin through ELISA, The parameters of fasting plasma glucose (FPG), total cholesterol (TC) and triglyceride (TG), fasting insulin level in plasma (FINS) and glycosylated hemoglobin(HbA1c) were measured, Insulin sensitive index ( ISI) and body mass index (BMI) were calculated, All calculations were performed using the SPSS 10.0 version for Windows. Results: Compared the clinical index among the three groups, the level of FPG, TC, TG, FINS, HbA1c and BMI in type 2 diabetes mellitus patients were significantly higher (P 0.01) and the concentration of plasma adiponectin and the level of ISI were significantly lower (P 0.01) than in the controls, and the concentration of plasma adiponectin is much lower in the group of type 2 diabetes with artherosclerosis than in group of type 2 diabetes without arth