HighFidelity DNA Hybridization using Programmable Molecular利用可编程分子的高保真核酸杂交.pptVIP

HIGH-FIDELITY HYBRIDIZATION: 2ND PROTOCOL HIGH-FIDELITY HYBRIDIZATION: 2ND PROTOCOL FAVORABLE PROPERTIES OF THE PROTOCOLS Autonomous Fluorophore based detection SIMULATION OF FINITE AUTOMATA Finite automata: Mathematical constructs that define languages Limited computational power Memoryless SIMULATION OF FINITE AUTOMATA Target strand encodes input to automata Checker sequences perform state transitions Green sequence performs δ(y,0) = z SIMULATION OF FINITE AUTOMATA Incorrect checker sequence may attach Further attachment is blocked as second hairpin doesn’t open At each step, pr