Pyogenic Bacterial Infections and Acute Bacterial 化脓性细菌感染和急性细菌性.pptVIP

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Pyogenic Bacterial Infections and Acute Bacterial 化脓性细菌感染和急性细菌性.ppt

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Pyogenic Bacterial Infections and Acute Bacterial 化脓性细菌感染和急性细菌性

Mycoplasma pneumoniae Smallest free-living bacteria (asymmetrical). No peptidoglycan cell wall-resistant to antibiotics that interfere with CW biosynthesis. Sterol in membrane. Slow growing (1-6 hr generation time). Extracellular pathogen. Adhere to respiratory epithelium via cytadherence. Destroy cilia and ciliated epithelial cells. Spread by nasal secretion (close contact necessary). Primary atypical (“walking”) pneumonia (age 6-20). Mechanisms to avoid host defenses Multiple serotypes Capsule Replicate inside host cells Atypical “cell wall” Other Adhesion Cause cell damage Staph/Strep Peter Coschigano, Ph.D. Department of Biomedical Sciences OUCOM 0 Outline Cell wall review Staphylococcal infections and virulence mechanisms Streptococcal infections and virulence mechanisms Other bacterial agents of pneumonia 0 Membrane Structure: /~sforza/prokaryote/cellwalls_compare.jpg Gram-negative Gram-positive Inner Membrane Outer Membrane Inner Membrane Peptido- glycan Peptidoglycan Periplasm Lipopolysaccharide (LPS) Teichoic acid Staphylococcus aureus epidermidis saprophyticus 0 Stained Staphylococcus aureus in tissues. [clumped, grape-like clusters of cocci] 10 μm Characteristics of Staphylococcus aureus Most common cause of human staphylococcal illness Ubiquitous in nature, normal carriage in 20-40% of people on skin, in anterior nares (nose), in vagina Resistant to heat desiccation b-hemolytic Can be spread by contact with inanimate objects (fomites) Illnesses Skin Infections Lung (pneumonia), blood (septicemia), systemic infection Toxin-mediated diseases: food poisoning, toxic shock syndrome, scalded skin syndrome 0 S. aureus -pathogenesis Host compromise needed for infection (break in skin, foreign body insertion, obstructed hair follicle) 0 S. aureus- skin infections Superficial abscesses (hair follicles, sweat glands, sebaceous glands) Subcutaneous abscess (furuncles and carbuncles = boils) Impetigo (localized, superficial, spreading, crusty lesion) Cell