核转录因子Nrf2与肺部炎症疾病进展_谢建林解剖.pdf

1080 Acta Pharmaceutica Sinica 2015, 50 (9): 1080?1087 Nrf2 ,,* ( , , 100050) : NF-E2 (nuclear factor erythroid 2-related factor 2, Nrf2) , (antioxidant response elements, ARE) , Nrf2-Keap1 (Kelch ECH 1)-ARE ,, ,, , PM2.5 , Nrf2 (chronic obstructive pulmonary disease, COPD) ALI) , Nrf2 , (acute lung injury, : NF-E2 : R963 ;; :A ; ;; : 0513-4870 (2015) 09-1080-08 Recent advances in the study of Nrf2 and inflammatory respiratory diseases XIE Jian-lin, LIN Ming-bao, HOU Qi* (Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China) Abstract: Nuclear factor-erythroid 2 related factor 2 (Nrf2) is an ubiquitous and important transcription factor. It regulates antioxidant response elements (AREs)-mediated expression of antioxidant enzyme and cytoprotective proteins. A large body of research showed that Nrf2-Keap1 (Kelch-like ECH-associated protein1, Keap1)-ARE signaling pathway is involved in the endogenous antioxidant defense mechanisms. Nrf2 increases the expression of a number of cytoprotective genes, protects cells and tissues from the injury of a variety of toxicants and carcinogens. As a result, Nrf2 enhances the expression of glutathione and antioxidants such as superoxide dismutase and glutathione S-transferase, and subsequently scavenging free radicals. Air pollution especially from PM2.5 particles, is associated with an increasing morbidity of inflammatory pulmonary diseases and their deterioration. More and more studies demonstrated that Nrf2 was a novel signaling molecule in the modulation of inflammatory responses in these inflammatory respiratory diseases, such as asthma, acute lung injury (ALI) and COPD. Therefore, Nrf2 targeting might be a therapeutic target, which will provide clinical benefit by reducing both oxidative stress and inflammation in asthma, acute lung injury (ALI) and COPD. This review focused on the relationship between Nrf2 and inflammatory respirato