右美托咪定对食管癌根治术患者围术期免疫功能的影响.docVIP

右美托咪定对食管癌根治术患者围术期免疫功能的影响 　　[摘要] 目的 探讨右美托咪定对食管癌根治术患者围术期免疫功能的影响。 方法 选取本院2014年1月～2015年1月收治的80例食管癌根治术患者作为研究对象，随机分为对照组和观察组，各40例。观察组麻醉诱导中给予右美托咪定，对照组给予0.9%氯化钠溶液，比较两组不同时间段的血糖、C反应蛋白（CRP）、T细胞亚群值、NK水平、CD4/CD8值以及IL-2、IL-10浓度。 结果 两组T2时的血糖、CRP水平显著高于T1时，差异有统计学意义（P0.05）。观察组T2时的血糖、CRP水平显著低于对照组，差异有统计学意义（P0.05）。两组T2、T3、T4时的CD3、CD4、CD8、CD4/CD8水平显著低于T1时，差异有统计学意义（P0.05）。观察组T2、T3、T4时的CD3、CD4、CD8、CD4/CD8水平显著高于对照组，差异有统计学意义（P0.05）。观察组T2时的NK值显著高于对照组，差异有统计学意义（P0.05）。观察组T2、T3时的IL-2水平显著高于对照组同时间段，T3、T4时的IL-10水平显著低于对照组同时间段，差异有统计学意义（P0.05）。 结论 右美托咪定应用于食管癌根治术可提高免疫功能，降低应激反应，值得临床推广应用。 　　[关键词] 右美托咪定；食管癌根治手术；免疫功能 　　[中图分类号] R735.1 [文献标识码] A [文章编号] 1674-4721（2016）04（c）-0052-04 　　Influence of dexmedetomidine on the immunologic function of patients with radical resection of esophageal cancer in the perioperative period 　　LIU Zhi-yi1 TANG Fang2 SONG Zhi-ping1 YIN Shi-ping1 CHEN Fu-mei1 WU Yong-qiang1 　　1.Department of Anesthesia，the First Affiliated Hospital of Nanchang University，Nanchang 330006，China；2.Department of Anesthesia，Children Hospital of Jiangxi Province，Nanchang 330006，China 　　[Abstract] Objective To explore the influence of dexmedetomidine on the immunologic function of patients with radical resection of esophageal cancer in the perioperative period. Methods 80 patients underwent radical resection of esophageal cancer in our hospital from January 2014 to January 2015 were selected and randomly divided into the control group and the observation group，40 cases in each group.The observation group was given dexmedetomidine during the anesthesia induction，and the control group was given 0.9% sodium chloride solution.The blood glucose level，C reaction protein （CRP） level，T cell subgroup value and NK level，the CD4/CD8 value，IL-2 and IL-10 concentration of the two groups in the different time periods was compared respectively. Results The level of blood glucose and CRP in T2 in the two groups was higher than that in T1，with significant difference （P 　　[Key words] Dexmedetomidine；Radical res