喷雾干燥过程条件对三七总皂苷_丹_省略_合粒子理化性质及肺部吸入性的影响_王华美解剖.pdf

Acta Pharmaceutica Sinica 2013, 48 (6): 925?932 A 925 ,,* (, , 210029) : 4 1; 3 : 110 (SEM) X , A , , :; : R943 , 120 130 (XRD) ? , , ?A 3: (DVS) (NGI) 91 110 , , ? (AFM) 7 , A (FPF ; :A A; ; : 0513-4870 (2013) 06-0925-08 , ) 91 , (HPLC) , 60% The influence of spray drying process conditions on physical, chemical properties and lung inhaling performance of Panax notoginseng saponins ? tanshinone A composite particles WANG Hua-mei, FU Ting-ming, GUO Li-wei* (Key Laboratory of Separation Engineering for Chinese Medicine Compound, Nanjing University of Chinese Medicine, Nanjing 210029, China)? Abstract: This study is to report the influence of conditions in spray drying process on physical and chemical properties and lung inhaling performance of Panax notoginseng Saponins ? Tanshinone II A composite particles. According to the physical and chemical properties of the two types of components within the composite particles, three solvent systems were selected including ethanol, ethanol acetone (9 1, v/v) and ethanol acetone (4 1, v/v), and three inlet temperature: 110 , 120 , 130 to prepare seven different composite particle samples; each sample was characterized using laser diffraction, scanning electron microscopy (SEM), dynamic vapour sorption (DVS) and atomic force microscope (AFM), and their aerodynamic behavior was evaluated by a Next Generation Impactor (NGI). The results indicate that under the conditions of using the mixed solvent system of ethanol ? acetone volume ratio of 9 1, and the inlet temperature of 110 , the resulting composite particles showed rough surface, with more tanshinone II A distributing in the outer layer, such composite particles have the best lung inhaling performance and the ?ne particle fraction (FPF) close to 60%. Finally it is concluded that : 2012-12-21; : 2013-01-23. : ; * Tel: 86-25 E-mail: guoliwei815@ (2011ZYX3-005). 926 Acta Pharmaceutica Sinica 2013, 48 (6): 925?932 by adjusting the conditions in co-spray dryin