新辅助化疗对直肠癌根治术后患者生存质量的影响分析.docVIP

新辅助化疗对直肠癌根治术后患者生存质量的影响分析 　　新辅助化疗对直肠癌根治术后患者生存质量的影响分析 　　【摘要】 目的：探讨新辅助化疗对直肠癌根治术后患者生存质量的影响。方法：选取2010年 　　1月-2013年1月本院收治的直肠癌患者100例作为研究对象，采用随机数字表法将其分为对照组和观察组，每组50例。所有患者均采用直肠癌根治术治疗，对照组术后辅助化疗6个疗程，观察组术前FOLFOX4新辅助化疗3个疗程+术后辅助化疗3个疗程，比较两组临床疗效、手术时间、术中出血量，术后并发症发生率、术后生存率及生活质量评分情况。结果：观察组肿瘤病灶R0切除率和缓解率均高于对照组，比较差异均有统计学意义（P0.05）；观察组随访率为100%（50/50），对照组随访率为96.00%（48/50），观察组术后1、3年生存率均高于对照组，比较差异有统计学意义（P0.05）；观察组生活质量评分评分低于对照组，比较差异有统计学意义（P0.05）。结论：新辅助化疗有助于改善直肠癌根治术后患者的临床疗效、生存率及生存质量，值得临床推广应用。 　　【关键词】 新辅助化疗； 直肠癌根治术； 生存质量 　　Impact Analysis of Patients Life Quality by Neoadjuvant Chemotherapy for Colorectal Cancer Radical Surgery/HONG Si-geng，LI Deng-song，LIU Jin-yan.//Medical Innovation of China，2016，13（27）：032-035 　　【Abstract】 Objective：To study the impact of patients life quality by neoadjuvant chemotherapy for colorectal cancer radical surgery.Method：From January 2010 to January 2013，100 cases of rectal cancer in our hospital were selected as the research objects，they were divided into the control group and the observation group according to the random number table method，each group had 50 cases.Two groups were given colorectal cancer radical treatment，the control group were given postoperative adjuvant chemotherapy for six sessions，the observation group were given FOLFOX4 neoadjuvant chemotherapy for three sessions+postoperative adjuvant chemotherapy for three sessions.The clinical curative effect，operation time，intraoperative blood loss，postoperative complications，postoperative survival rate and life quality score of two groups were compared.Result：The tumor R0 resection and remission rate of the observation group were significantly higher than those of the control group，the differences were statistically significant（P0.05）.The observation group followed-up rate was 100%（50/50），the control group followed-up rate was 96.00%（48/50），the postoperative 1，3 years survival rate of observation group were higher than those of the control group，the differences were statistically significant（P