热毒宁联合黄芪注射液治疗小儿手足口病并发性心肌炎的疗效观察.docVIP

热毒宁联合黄芪注射液治疗小儿手足口病并发性心肌炎的疗效观察 　　【摘要】 目的：探讨热毒宁联合黄芪注射液治疗小儿手足口病并发性心肌炎的临床疗效。方法：将66例手足口病并发性心肌炎患儿随机分为对照组和治疗组，各33例，对照组采用吸氧、抗病毒、改善心肌代谢及其他对症治疗，治疗组在对照组综合治疗的基础上给予热毒宁联合黄芪注射液治疗，比较两组的治疗效果和血清肌酸激酶同工酶（CK-MB）及乳酸脱氢酶（LDH）水平。结果：对照组和治疗组的总有效率分别为69.7%和93.9%，差异有统计学意义（P0.05）。治疗组的CK-MB和LDH水平较之治疗前明显降低，差异有统计学意义（P0.05）。结论：热毒宁联合黄芪注射液治疗小儿手足口病并发性心肌炎疗效显著，值得临床推广使用。 　　【关键词】 热毒宁； 黄芪注射液； 小儿手足口病并发性心肌炎 　　中图分类号 R51 文献标识码 A 文章编号 1674-6805（2014）17-0004-03 　　【Abstract】 Objective：To explore the clinical curative effect of Reduning combined with Astragalus Injection in the treatment of children with hand foot and mouth disease complicated by myocarditis.Method：66 cases of children with hand foot and mouth disease complicated by myocarditis were randomly divided into control group and treatment group，33 cases in each group，control group adopted the oxygen，antivirus，improving myocardial metabolism and other symptomatic treatment，treatment group adopted Reduning combined with Astragalus Injection treatment on the basis of comprehensive treatment of control group，the treatment effect，serum creatine kinase isoenzyme（CK-MB） and lactate dehydrogenase （LDH） level of two groups were compared.Result：The total effective rate of control group and treatment group were 69.7% and 93.9% respectively， the difference was statistically significant（P0.05）.The CK-MB and LDH levels of treatment group were significantly lower than before treatment， the differences were statistically significant（P0.05）.Conclusion：The curative effect of Reduning combined with Astragalus Injection in the treatment of children with hand foot and mouth disease complicated by myocarditis is distinct，worth clinical promotion. 　　【Key words】 Reduning； Astragalus Injection； Children with hand foot and mouth disease complicated by myocarditis 　　First-author’s address：Huguang People’s Hospital of Zhanjiang City，Zhanjiang 524088，China 　　手足口病（hand foot and mouth disease，HFMD）是一种常见由肠道病毒感染引起的急性传染病，主要表现为发热、手足皮肤、口腔黏膜、臀部皮肤疱疹、溃疡，少数患儿可引起心肌炎、肺水肿、无菌性脑膜脑炎等并发症。4岁以