腹腔镜术后应用戈舍瑞林和孕三烯酮的效果差异及对受孕率的影响.docVIP

腹腔镜术后应用戈舍瑞林和孕三烯酮的效果差异及对受孕率的影响 　　[摘要] 目的 探讨戈舍瑞林和孕三烯酮应用于腹腔镜术后的治疗方法，评估其临床前景。 方法 选择2014年5月1日～2015年5月1日于我院行腹腔镜卵巢巧克力囊肿剔除术患者56例，采用随机数字表法将其分为观察组（戈舍瑞林治疗）与对照组（孕三烯酮治疗），各28例，比较两组患者治疗后激素指标、复发率、受孕率及临床症状改善情况，分析其应用价值。 结果 两组患者治疗后LH、FSH指标及临床症状改善情况比较，差异无统计学意义（P0.05），与治疗前比较，两组治疗后E2指标均显著降低（P0.05）；与对照组比较，观察组E2指标明显下降，复发率明显降低，受孕率明显升高（P0.05）。 结论 戈舍瑞林应用于腹腔镜卵巢巧克力囊肿剔除术后可有效降低E2激素指标与复发率，提高受孕率，值得临床应用。 　　[关键词] 腹腔镜术；戈舍瑞林；孕三烯酮；受孕率 　　[中图分类号] R711.75 [文献标识码] A [文章编号] 1674-4721（2016）03（b）-0144-03 　　[Abstract] Objective To explore the treatment method of goserelin and gestrinone in postoperative laparoscopic and to value its clinical prospect. Methods 56 patients with laparoscopic ovarian chocolate cyst removed of our hospital from May 1，2014 to May 1，2015 were selected.Patients were randomly divided into observation group（goserelin treated） and control group（estrinone treated） by using numner methods，and each group was 28 cases.The hormon index，recurrence rate，conception rate and clinical symptoms improvement after treatment between two groups were compared and its application value was analyzed. Results After treatment，the index of LH and FSH and clinical symptoms improvement between two groups had no statistical significance（P0.05）.Compared with before treatment，the index of E2 between two groups was obvious decreased after treatment（P0.05）.Compared with control group，the index of E2 in observation group was obvious decreased，recurrence rate decreased obviously while conception rate increased obviously（P0.05）. Conclusion Goserelin in laparoscopic ovarian chocolate cyst removed can decrease the E2 hormon index and recurrence rate，but increase conception rate effectively.It is worth to application in clinic. 　　[Key words] Laparoscopic；Goserelin；Gestrinone；Conception rate 　　卵巢巧克力囊肿发病率较高，是妇科良性肿瘤中较为常见的激素依赖性疾病，患者易因月经紊乱、小腹隐痛及痛经等症状而导致不孕不育，严重威胁患者的身心健康[1-2]。腹腔镜因具有术中出血少、减少纱布等对组织的损伤、避免脏器的暴露、腹壁瘢痕小、住院时间短等优点，成为临床上目前治疗卵巢巧克力囊肿的首选方式。虽然行腹腔镜术可有效分离粘连、清除病灶，但是该病灶周围血管丰富、病变广泛、盆腔粘连严重等，行腹腔镜术微小病灶的清除效果不佳，非典型性病灶或极小病灶无法通