降钙素原检测在产褥感染诊断中的应用.docVIP

降钙素原检测在产褥感染诊断中的应用 　　【摘要】 目的：对降钙素原（procalcitonin，PCT）检测在产褥感染诊断中的临床应用价值进行评价分析。方法：选取2015年1-3月于本院住院分娩产妇1030例作为研究对象，其中分为临床诊断感染组195例、产后低热组135例及对照组700例，对所有产妇展开PCT定量检测，对比分析检测结果。结果：以PCT≥0.5 ng/mL作为阈值时预测产妇感染，临床诊断感染组、产后低热组感染率分别为15.384%、8.148%均高于对照组的3.285%，三组比较差异均有统计学意义（P0.05）。临床诊断感染组经抗生素抗感染治疗，产后低热组给予抗生素预防感染，均转归良好。结论：PCT检测在产妇感染诊断方面特异性显著，对产褥感染的诊断有一定的临床指导意义。 　　【关键词】 降钙素原； 产褥期感染； 产褥病率 　　【Abstract】 Objective：To evaluate and analyze the clinical application value of procalcitonin（PCT） detection in the diagnosis of puerperal infection.Method：From January to March in 2015，1030 delivery women in our hospital were selected as the research objects，they were divided into the 195 cases of clinical diagnosis infection group，135 cases of postpartum low fever group and 700 cases of control group.The PCT quantitative detection of all maternal were carried on，the results were compared and analyzed.Result：PCT was more than or equal to 0.5 ng/mL as the threshold predicted maternal infection，the infection rate of clinical diagnosis infection group and postpartum fever group were respectively 15.384% and 8.148%，they were higher than those of the control group 3.285%，compared three groups，the differences were statisticalily significant（P0.05），the clinical diagnosis infection group was treated by antibiotic therapy，postpartum low fever group was given antibiotics to prevent infection，they were all good prognosis.Conclusion：PCT test has specificity significantly in the diagnosis of maternal infection，and has some clinical significance in the diagnosis of puerperal infection. 　　【Key words】 Procalcitonin； Puerperal infection； Puerperal morbidity 　　产褥期感染是产褥期最严重的并发症，发病率为1%～8%，与产科出血、妊娠期严重的高血压疾病为导致产妇死亡的三大主要原因[1-2]。产褥感染指分娩及产褥期生殖道受病原体侵袭，引起局部或全身感染，三大主要症状为发热、疼痛、异常恶露。产褥期感染又称为产褥期发热或产褥热，主要是由产褥感染引起，还可由生殖道以外的原因引起，如呼吸系统感染、泌尿系统感染、乳腺内乳汁淤积、药物热、血栓形成等。产褥病率指分娩24 h以后的10 d内发生的产后发热，其检测体温方式为4 次/d，间隔时间不超过4 h，其中有至少两次体温≥38.0 ℃。产褥早期发热的最常见原因是脱水，但持续2～3 d低热后又突然出现高热，应是感染所致。胎膜早破可增加感染发病率，但本院胎膜早破达12 h未分娩则应用抗生素预防感染，故胎膜早破的感染率比较低3.