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Predicting acute contact toxicity of pesticides in honeybees (Apis mellifera) through a k-nearest neighbor model.pdf

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Predicting acute contact toxicity of pesticides in honeybees (Apis mellifera) through a k-nearest neighbor model.pdf

Chemosphere 166 (2017) 438e444 Contents lists available at ScienceDirect Chemosphere journal homepage: /locate/chemosphere Predicting acute contact toxicity of pesticides in honeybees (Apis mellifera) through a k-nearest neighbor model F. Como a, *, E. Carnesecchi b, S. Volani b, J.L. Dorne b, J. Richardson b, A. Bassan c, M. Pavan c, E. Benfenati a a IRCSS Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, 20146 Milano, Italy b European Food Safety Authority, Via Carlo Magno 1A, 43126 Parma, Italy c S-IN Soluzioni Informatiche S.r.l., via G. Ferrari 14, 36100 Vicenza, Italy highlights A model to predict acute contact toxicity for bees was built for screening pesticides. The model developed will address future risk assessments of pesticides of concern. The accuracy of k-NN model is good and equal to 65% for the highly toxic compounds. article info Article history: Received 29 June 2016 Received in revised form 9 September 2016 Accepted 21 September 2016 Available online 2 October 2016 Handling Editor: Jim Lazorchak Keywords: Pesticides Honey bees k-NN In silico models Acute contact toxicity Abbreviations: EFSA European Food Safety Authority US-EPA Unites States Environmental Protection Agency k-NN K-Nearest Neighbor LD50 Dose killing half the test organisms after a speci?ed test duration MCC Matthew Correlation Coef?cient OECD Organization for Economic Co-operation and Development abstract Ecological risk assessment of plant protection products (PPPs) requires an understanding of both the toxicity and the extent of exposure to assess risks for a range of taxa of ecological importance including target and non-target species. Non-target species such as honey bees (Apis mellifera), solitary bees and bumble bees are of utmost importance because of their vital ecological services as pollinators of wild plants and crops. To improve risk assessment of PPPs in bee species, computational models predicting the acute and chronic toxicity of a range of PPPs