干细胞标志Nanog在食管鳞癌组织中表达及预后关系.docVIP

干细胞标志Nanog在食管鳞癌组织中表达及预后关系 　　摘要：目的 探讨食管鳞癌组织中干细胞标志Nanog表达及其与肿瘤病理特征和预后的关系。方法 采用免疫组化方法测定60例食管鳞癌组织和10例癌旁组织中干细胞标志Nanog的表达情况，比较它在组织中的表达差异，及其与食管癌相关临床病理特征和预后的关系。结果 在60例患者中，26例出现复发转移，Nanog在转移组中表达率分别为61.5%（16/26），在非转移组中分别为26.5%（9/34），差异有统计学意义，P值0.05）。Nanog为阳性表达其转移率显著高于为阴性表达者。结论 食管鳞癌组织中Nanog 表达与患者术后复发转移有一定关系，该检测有助于预后的评价。 　　关键词：食管鳞癌；Nanog 　　Expression and Clinical Significances of Nanog in Esophagea Squamous Carcinoma 　　MA Cheng-fang1， YU Zheng2， LI Shao-peng1， LI Zhi-hua1， WEI Chun-yong1， WANG Li-xu1， HONG Qiong-chuan1 　　（1.Department of Cardiothoracic Surgery， Longgang District Central Hospital of Shenzhen，Shenzhen 518116， Guangdong，China； 　　2. Department of Physical Examination， People Hospital of Shenzhen Longgang District，Shenzhen 518116， Guangdong，China） 　　Abstract：Objective To investigate the expression of Nanog in esophageal squamous carcinoma and their correlations with the pathologic parameter of cancer and prognosis.Methods The expression of Nanog in 60 surgical specimens of esophageal squamous carcinoma and 10 paracarcinoma tissues was detected by immunohistochemistry method. The correlations between the expression of Nanog and the clinical pathological characteristics were analyzed statistically.Results Relapse and metastasis of 26 cases was detected in all patients. In metastasis group， the positive expression rate of Nanog was 61.5 %（16/26））. And the positive expression rate of Nanog in non-metastasis group was 26.5%（9/34）.The difference was signigicant （ P 0. 05）. Expression of Nanog signigicantly correlated with differentiation， but was not associated with T stage or N stage . Metastatic rate in positive expression was higher than in negative expression.Conclusion The expression of Nanog related with progression and prognosis of esophageal squamous carcinoma， they are both hopeful predictors for patients with esophageal squamous carcinoma. 　　Key words：Esophageal squamous carcinoma；Nanog 　　食管癌是我??高发肿瘤之一，食管鳞癌术后的复发转移是目前临床常见的现象，总体治疗效果不佳，如何有效的评估预测是目前国内外