地佐辛与芬太尼用于悬雍垂腭咽成形术后镇痛的评价.PDFVIP

一校 天津医药 20 12 年 9 月第 40 卷第 9 期 895 doi:10.3969/j.issn.0253-9896.2012.06.001 地佐辛与芬太尼用于悬雍垂腭咽成形术后镇痛的评价 赵 森 吕国义 孙成亮 邓廼封 李 波 摘要 目的 探讨地佐辛与芬太尼用于悬雍垂腭咽成形术渊UPPP冤术后患者行静脉自控镇痛渊PCIA冤的有效性及 安全性遥方法 40 例择期行UPPP 的阻塞性睡眠呼吸暂停综合征患者袁随机分为芬太尼组渊F 组冤和地佐辛组渊D 组冤袁 每组20 例遥UPPP 术后行 PCIA 袁观察患者术后1尧3尧6尧12尧24 h 时的镇痛效果遥结果 2 组患者均镇痛良好遥F 组术后 1 h 镇痛效果好于 D 组袁但存在镇静过度渊P 0.05 冤袁其余时间点 2 组差异无统计学意义渊P 0.05 冤遥2 组患者 PCIA 按压次数差 无统计学意义渊P 0.05 冤遥 F 组术后 1~3 h 平均动脉压尧心率和术后 1 h 脉搏血氧饱和度低于D 组 渊P 0.05 或P 0.01 冤遥F 组恶心呕吐及呼吸抑制发生率高于D 组渊P 0.05 冤袁其余不良反应2 组差 无统计学意义 渊P 0.05 冤遥 结论 地佐辛应用于阻塞性睡眠呼吸暂停综合征患者 UPPP 术后 PCIA 效果确切袁较芬太尼更为安全遥 关键词 芬太尼 悬雍垂 腭 咽 外科手术 睡眠呼吸暂停袁阻塞性 镇痛袁病人控制 地佐辛 The Evaluation of Postoperative Analgesia of Dezocine and Fentanyl in Patients with Uvulopalatopharyngiplasty Surgery ZHAO Sen, L譈 Guoyi 袁SUN Chengliang 袁DENG Naifeng 袁LI Bo Second Hospital of Tianj in Medical Unive rs ity, Tianj in 300211, China Abstract Obj ective: To evaluate the efficiency and safety of patient-controlled analgesia (PCIA) with dezocine and fentanyl after uvulopalatopharyngiplasty (UPPP) surgery. Methods: Forty patients underwent UPPP surgery for PCIA were randomly divided into two groups: group F (fentanyl 16 滋g/kg, n =20) and group D (dezocine 0.8 mg/kg, n =20). Postoperative analgesia was assessed 1 h, 3 h, 6 h, 12 h and 24 h after operation. Results: Patients in both groups showed similar results in pain relief. The analgesic effect was higher 1h after surgery in group F than that of group D, but there was deep sedation(P 0.05). There were no significant differences in other time points after operation between two grou