注射用水溶性維生素组合包装与36种常用治疗药物的.docVIP

注射用脂溶性维生素（Ⅱ）/注射用水溶性维生素组合包装与36种常用治疗药物的配伍研究 韦国翠*，余澜，詹先成#，谭晓莹，王晓兰 （四川大学华西药学院，成都市 610041） 摘要：目的：考察注射用脂溶性维生素（Ⅱ）/注射用水溶性维生素组合包装与36种临床常用治疗药物的配伍变化。方法：样品溶液配制后于0、4、8小时分别观察其色泽、性状及沉淀，并用pH计测定pH值。结果与结论：注射用脂溶性维生素（Ⅱ）/注射用水溶性维生素组合包装与注射用兰索拉唑配伍，4小时观察有白色沉淀，本品不宜与其配伍；与注射用夫西地酸钠配伍，4小时观察有絮状悬浮物，本品不宜与其配伍；与注射用奥美拉唑钠配伍，配制时产生絮状物，半分钟内消失；与其余33种药物配伍，8小时内无沉淀产生，外观色泽目测无变化，pH值无显著改变 关键词：注射用脂溶性维生素（Ⅱ）/注射用水溶性维生素组合包装；药物配伍；稳定性 Compatibility of Fat-soluble Vitamin(Ⅱ) for Injection/Water-soluble Vitamin for Injection Collective Packing With 36 Commonly-used Drugs WEI Guocui，YU Lan，ZHAN Xiancheng，TAN Xiaoying，WANG Xiaolan(West China School of Pharmacy, Sichuan University, Chengdu 610041, China) ABSTRACT: OBJECTIVE: The physical compatibility of Fat-soluble Vitamin(Ⅱ) for Injection/Water-soluble Vitamin for Injection Collective Packing with commonly used medications was evaluated. METHODS: The sample solutions were inspected for visual, precipitation and pH changes immediately after preparation and 4 and 8 hours after preparation. RESULTS CONCLUSION: Fat-soluble Vitamin (Ⅱ) for Injection/Water-soluble Vitamin for Injection Collective Packing was physically compatible with 33 drugs in all test solutions, exhibiting color similar to those of control solutions. No substantial changes in pH and precipitation were observed over the 8-hour study period. It was incompatible with Lansoprazole for injection and Sodium Fusidate for Injection because the mixture resulted in precipitation. The mixture of it with Omeprazole appeared precipitation and the precipitation dissolved in half minute KEY WORDS: Fat-soluble Vitamin(Ⅱ) for Injection/Water-soluble Vitamin for Injection Collective Packing; compatibility; stability *硕士研究生。研究方向：药物稳定性。电话 E-mail：通讯 E-mail：xczhan@mail.sc.cninfo.netpH值的变化，以期为临床应用提供参考。 药品与仪器·mL-1。 配伍变化检查： 样品溶液配制后于0、4、8小时分别灯检观察其色泽、性状及沉淀，并用pH计 the compatibility test of Fat-soluble Vitamin(Ⅱ) for Injection/Water-soluble Vitamin for Injection Collective Packing with 36 c