考研资料:北京大学细胞生物学第十一章细胞增殖极其调控[下].pptVIP

考研资料:北京大学细胞生物学第十一章细胞增殖极其调控[下].ppt

  1. 1、本文档共37页,可阅读全部内容。
  2. 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
  3. 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载
  4. 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
  5. 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
  6. 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们
  7. 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
  8. 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
考研资料:北京大学细胞生物学第十一章细胞增殖极其调控[下]

3. Cytokinesis (1) In animal cells (2) In plant cells: The phragmoplast guides cytokinesis in higher plants; The mechanisms cotrolling S-phase initiation in animal cells. The Rb protein acts as a brake in mammalian G1 cells The control of G1 progression and S-phase initiation is often disrupted in cancer cells,leading to unrestrained cell-cycle entry and cell proliferation. Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. Mitogens stimulate G1-Cdk and G1/S-Cdk activities A simplified model of one way that mitogens stimulate cell division Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. DNA damage checkpoint: Cell-cycle progression is blocked by DNA damage and p53 How DNA damage arrests the cell cycle in G1. Two such checkpoints: 1.One in late G1: provents entry into S phase; 2.One in late G2: provents entry into mitosis; P53: gene regulatory protein.DNA damage activates p53 by an indirect mechanism. Mdm2 acts as a ubiquitin ligase that targets p53 for destruction by proteasomes. Phosphrylated p53 reduce its binding to Mdm2. P21(CKI protein) binds to G1/S-Cdk and S-Cdk and inhibits their activities, thereby helping to block entry into S phase. Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. * * The MT of mitotic spindle determine the plane of animal cell division; Mitosis can occur without cytokinesis. Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. Contractile ring: Actin and myosinII in the contractile ring generate the force for cytokinesis Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. The assembly of the cell plate begins in late anaphase and is guided by phragmoplast Evaluation only. Created with Aspose.Slides for

文档评论(0)

jdy261842 + 关注
实名认证
文档贡献者

分享好文档!

1亿VIP精品文档

相关文档