CardiacMuscleMech.ppt

* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * 1-2-3 Isotonic 1-4-5 Afterloaded 2.9 MH Relaxation “COUNTER CLOCKWISE ROTATION” Mohrman and Heller. Cardiovascular Physiology. McGraw-Hill, 2006. 6th ed. * Terms Related to Cardiac Performance Preload - The ventricular wall tension at the end of diastole. Afterload -- The ventricular wall tension during contraction; the resistance that must be overcome for the ventricle to eject its contents. Approximated clinically by systolic ventricular or arterial pressure. * Afterloaded contraction (length-tension) Afterloaded contraction (volume-pressure) LaPlace Wiggers diagram Stroke volume Ejection Fraction Cardiac Output Right pump Preload (Frank-Starling), Afterload, Contractility Tuesday 10/28/08, 11:00Cardiac Muscle II22 Slides, 50 min * 3.3 MH active passive stretch COUNTER CLOCKWISE ROTATION Mohrman and Heller. Cardiovascular Physiology. McGraw-Hill, 2006. 6th ed. * 3.3 MH Ejection Fraction = 70/130 = 54% ventricular systole diastolic filling COUNTER CLOCKWISE ROTATION Pressure increases as radius decreases. LV end-diastolic Volume **** LVEDV **** Mohrman and Heller. Cardiovascular Physiology. McGraw-Hill, 2006. 6th ed. * Law of La Place T = P x r (see page 44 of MH) The tension (T) in the ventricular wall depends upon both the pressure (P) in the chamber and the radius (r) of the chamber. Thus as the ventricle gets smaller during ejection the pressure within increases even at the same muscle tension. Same T = P x r * COUNTER CLOCKWISE ROTATION Source Undetermined * Top 3.1 MH C = isovolumetric contraction D = isovolumetric relaxation Ventricular A = diastole B = ventricular systole Time on x axis 2 1 3 Three Pressures mmHg Mohrman and Heller. Cardiovascular Physiology. McGraw-Hill, 2006. 6th ed. * Systole Diastole Text books vary in definitions but the more common uses of the unmodified terms “systole” and “diastole” are: Systole i