原创力文档- 1、本文档共59页，可阅读全部内容。
- 2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
- 3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
查看更多
chpPro-treatmentofsample
Chapter 3 Sample preparation and Validation of analytical method Section 1 Work-up procedures prior to analysis ——Sample preparation 1.1 General Considerations Halogen-containing drugs ——organic halides, halogenides Organo-metal drugs (organometallic drugs) ——organic metals ——metal-containing compounds (organic metallic salts) Organic halides 泛影酸 碘番酸 三氯叔丁醇 磺溴酞钠 Organic metals 酒石酸锑钾 富马酸亚铁 Metal-containing compounds 卡巴胂 1.2 Determination non-organic degradation (1) direct determination such as: Ferrous fumarate — may dissolve in hot diluted mineral acid and yield the ferrous ion, can be titrated using ceric sulfate VS. **cerium(Ⅲ), ceric(Ⅳ,高价), cerous(Ⅱ,低价). (2) determination after hydrolysis (reflux) application: the halogen was not firmly connected to drug —— to halogen no double bonded carbon atom was connected (aliphatic halide). ① alkaline hydrolysis Dissolve organic halide in a suitable Solution, such as alcohol, add sodium hydroxide solution or silver nitrate VS, reflux to make organic halide change into inorganic halide (NaX or AgX), then (add AgNO3VS) titrate using the ammonium thiocyanate (NH4SCN) VS. for example: determination of Chlorobutanol ② acid hydrolysis,such as magnecium stearate (3) Determination after oxido-reduction application: iodine-containing compound that iodine was firmly connected to double-bonded carbon atom — benzene ring ① alkaline reduction dissolve organic halide in a sodium hydroxide solution (
文档评论（0）