chapter43antifungalandantiviralagents.pptVIP

Chapter 43 Antifungal and Antiviral Agents Department of pharmacology Liu xiaokang(刘小康） 2010,3 Antifungal Agents Drugs categorized multiple bases: (1) Type of infection: (a) Systemic (Deep) Fungal infections. (b) Topical (Dermatophytic) Fungal infections. (c) Mucous membranes -- Yeast infections. (2) Route/Site of action. (3) Mechanism of action. (4) Chemical nature. Basis for some selectivity: Bacteria: Prokaryotes, Have cell wall, Key membrane lipid = hydroxylated glycerols Fungi: Eukaryotes, Have cell wall, Key membrane lipid = ergosterol Vertebrates: Eukaryotes, NO cell wall, Key m